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卵巢成熟性囊性畸胎瘤癌变为小细胞癌混合鳞状细胞癌1例

Mature cystic teratoma of the ovary with squamous cell carcinoma mixed small cell neuroendocrine carcinoma:report of a case
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摘要 卵巢成熟性囊性畸胎瘤癌变(malignant transformation of ovarian mature cystic teratoma,MCT)较罕见。本文报道1例卵巢成熟性囊性畸胎瘤,灶区伴小细胞神经内分泌癌混合鳞状细胞癌变(小细胞癌约占60%,鳞状细胞癌约占40%)。本例小细胞癌区域CD56、突触素阳性以及Ki-67阳性指数高表达至80%,p40、细胞角蛋白(CK)5/6阴性,提示神经内分泌癌分化;鳞状细胞癌癌变区域p40、CK5/6阳性,CD56、突触素阴性;两种癌变区域p53及p16均阴性。该疾病主要与宫颈或阴道的鳞状细胞癌、胃肠道低分化腺癌、泌尿系统的尿路上皮癌、呼吸道及胃肠道小细胞癌转移、卵巢粒层细胞瘤相鉴别。此病以手术全切除为主,术后辅以系统性放、化疗。
作者 吴龙波 孔雪 Wu Longbo;Kong Xue(Department of Pathology,Lujiang People's Hospital,Hefei 231500,China;Department of Pathology,the First Affiliated Hospital of University of Science and Technology of China,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230031,China)
出处 《中华病理学杂志》 CAS CSCD 北大核心 2023年第10期1050-1052,共3页 Chinese Journal of Pathology
作者简介 通信作者:孔雪,Email:kongxue007@ustc.edu.cn。
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