摘要
昼夜节律是大多数生物体生理过程中以24 h左右为周期的循环,昼夜颠倒、衰老等因素会导致昼夜节律紊乱。一些特殊职业人群及老年人的昼夜节律紊乱往往与精神疾病相关,比如焦虑、抑郁、阿尔茨海默症等等。研究发现肠道微生物可以同时影响昼夜节律及精神健康,而饮食又可以影响肠道微生物。为此,该文综述了昼夜节律、肠道微生物与精神健康之间的关系,以及饮食干预对节律紊乱和神经疾病的改善,为精神疾病的发病机制和诊治提供新的视角。
Circadian rhythm is a cycle that takes about 24 h as a cycle in most biological physiological processes.The reversal of day and night,aging and other factors will lead to the disorder of circadian rhythm.The circadian rhythm disorder of some special occupational groups and the elderly is often related to mental diseases,such as anxiety,depression,Alzheimer’s disease,and so on.Studies have found that intestinal microbes can simultaneously affect circadian rhythm and mental health,while diet can affect intestinal microbes.Therefore,this article reviews the relationship between circadian rhythm,intestinal microbes and mental health,as well as the improvement of dietary intervention on rhythm disorders and neurological diseases,providing a new perspective for the pathogenesis and diagnosis and treatment of mental diseases.
作者
田杰
张怡琳
万嗣宝
游春苹
TIAN Jie;ZHANG Yilin;WAN Sibao;YOU Chunping(State Key Laboratory of Dairy Biotechnology,Shanghai Engineering Research Center of Dairy Biotechnology,Dairy Research Institute,Bright Dairy&Food Co.,Ltd.,Shanghai 200436,China;School of Life Science,Shanghai University,Shanghai 200444,China)
出处
《食品与发酵工业》
CAS
CSCD
北大核心
2023年第19期329-337,共9页
Food and Fermentation Industries
基金
上海市优秀技术带头人计划(20XD1430100)
上海乳业生物工程技术研究中心资助项目(19DZ2281400)。
关键词
昼夜节律
精神健康
肠道微生物
饮食
circadian rhythm
mental health
intestinal microbes
diet
作者简介
第一作者:田杰,硕士研究生;通信作者:游春苹,正高级工程师,E-mail:youchunping@brightdairy.com。
