摘要
萎缩性胃炎(Atrophic Gastritis,AG)是重要的胃癌前病变,临床对于AG及胃癌的确诊须依赖胃镜及组织学检查,但上述检测手段为有创性操作且费用相对较高,我国是人口大国,此方法不适用于AG及胃癌的大规模筛查。部分患者症状不典型,易漏诊误诊,就诊时已处于病变中晚期。因此,我们需要简单、经济,且能在门诊常规开展的筛查手段,以求做到对AG及胃癌的早发现。研究显示幽门螺杆菌(Helicobacter pylori,Hp)感染是胃癌的独立危险因素,血清胃蛋白酶原和胃泌素-17是反映胃黏膜状态和功能的重要指标,大量研究证实上述三者的检测是诊断AG及评估胃癌风险的重要依据。随着中医学的不断发展,临床研究证实,中医药在治疗AG方面具有独特优势,其通过干预上述胃黏膜相关指标可有效改善胃黏膜炎症,促进胃黏膜修复,阻止或逆转胃癌前病变。文章旨在对相关文献进行综述,以阐明三者在协助诊断AG及胃癌风险评估中的有效性。
Atrophic gastritis is an important precancerous lesion of gastric cancer.The clinical diagnosis of atrophic gastritis and gastric cancer relies on gastroscopy and histological examination,but the above detection methods are invasive and relatively expensive.China with a large population,this method is not suitable for large-scale screening of atrophic gastritis and gastric cancer.Some patients have atypical symptoms,which are easy to be missed in diagnosis and misdiagnosed.They are already in the middle and late stages of the disease at the time of treatment.Therefore,simple,economical and routine screening methods in outpatient clinics to achieve early detection of atrophic gastritis and gastric cancer are needed.Studies have shown that Helicobacter pylori infection is an independent risk factor for gastric cancer.Serum pepsinogen and gastrin-17 are important indicators of gastric mucosal status and function.A large number of studies have confirmed that the detection of the above three indicators is an important basis for the diagnosis of atrophic gastritis and the assessment of gastric cancer risk.With the continuous development of traditional Chinese medicine,clinical studies have confirmed that traditional Chinese medicine has unique advantages in the treatment of atrophic gastritis.It can effectively improve gastric mucosal inflammation,promote gastric mucosal repair,and prevent or reverse gastric precancerous lesions by interfering with the above gastric mucosal related indicators.Therefore,this article aims to review the relevant literature to clarify the effectiveness of the three indicators in assisting in the diagnosis of atrophic gastritis and gastric cancer risk assessment.
作者
马玉秀
肖君
MA Yuxiu;XIAO Jun
出处
《中医临床研究》
2023年第21期118-123,共6页
Clinical Journal Of Chinese Medicine
基金
江苏省中医药科技发展专项(2020ZX07)。
作者简介
马玉秀(1996-),女,甘肃天水人,回族,南京中医药大学2021级中西医结合临床硕士研究生,研究方向为消化系统疾病的中西医结合治疗;通讯作者:肖君(1979-),女,江苏南京人,医学博士,主任中医师,硕士研究生导师,研究方向为消化系统疾病的中西医结合治疗。
