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氧化应激因子与急性冠脉综合征患者冠脉狭窄程度的相关性 被引量:1

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摘要 目的探究氧化应激因子与急性冠脉综合征患者冠脉狭窄程度的相关性。方法选取我院2020年5月~2022年5月符合标准的108例急性冠脉综合征患者作为观察组,并根据Gensini积分及临床检查分析确定患者的冠脉狭窄程度,分为重度组(n=32)、中度组(n=34)、轻度组(n=42);另选择同期冠脉造影检查为阴性,未出现明显冠脉狭窄者95例作为对照组。对比各组患者氧化应激因子的水平,并分析氧化应激因子与患者冠脉狭窄程度的相关性。结果观察组的Lp-PLA2水平高于对照组(P<0.05),观察组的AT-Ⅲ水平低于对照组(P<0.05);冠脉狭窄中度组的Gensini积分与Lp-PLA2水平高于轻度组(P<0.05),中度组的AT-Ⅲ水平低于轻度组(P<0.05);重度组的Gensini积分与Lp-PLA2水平高于轻度组和中度组(P<0.05),重度组的AT-Ⅲ水平低于轻度组和中度组(P<0.05);Spearman相关性分析显示,急性冠脉综合征患者血清中AT-Ⅲ水平与Gensini积分呈负相关(r=-0.329,P<0.05),Lp-PLA2水平与Gensini积分呈正相关(r=0.279,P<0.05)。结论急性冠脉综合征患者的冠脉狭窄程度和氧化应激因子存在一定的相关性,与血清中AT-Ⅲ水平呈负相关,与血清中Lp-PLA2水平呈正相关,血清氧化应激因子在一定程度上有助于急性冠脉综合征患者冠脉狭窄程度的预测。
出处 《医师在线》 2023年第9期52-54,共3页 Journal of Doctors Online
基金 保定市科技计划项目(2141ZF254)。
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