摘要
目的探讨腹腔镜下胆囊切除术治疗急性胆囊炎患者的临床效果。方法150例急性胆囊炎患者,采用随机数字表法分为对照组及实验组,每组75例。对照组给予常规治疗,实验组实施腹腔镜下胆囊切除术治疗。比较两组治疗前后的生活质量[生活质量(QOL)评分]、机体炎症指标[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)]水平,手术切口长度、手术时间、术中出血量、住院时间,并发症发生情况。结果治疗后,两组QOL评分高于本组治疗前,TNF-α、hs-CRP、IL-6低于本组治疗前,且实验组QOL评分(93.56±3.25)分高于对照组的(83.12±3.03)分,TNF-α(1.51±0.21)ng/ml、hs-CRP(7.12±1.02)mg/L、IL-6(61.13±2.16)pg/ml低于对照组的(2.41±0.28)ng/ml、(9.25±1.56)mg/L、(121.21±2.11)pg/ml,差异具有统计学意义(P<0.05)。实验组手术切口长度(2.92±0.62)cm、手术时间(41.02±8.92)min、住院时间(4.12±1.52)d短于对照组的(9.72±3.22)cm、(68.33±10.32)min、(9.33±2.62)d,术中出血量(30.42±2.32)ml少于对照组的(75.33±10.64)ml,差异具有统计学意义(P<0.05)。实验组并发症发生率2.67%低于对照组的13.33%,差异具有统计学意义(P<0.05)。结论急性胆囊炎患者实施腹腔镜下胆囊切除术治疗效果确切,可有效控制机体炎症,且相对于开放手术,其切口更短,出血量及并发症更少,有利于更好地改善患者术后的生活质量。
Objective To discuss the clinical effect of laparoscopic cholecystectomy on patients with acute cholecystitis.Methods A total of 150 patients with acute cholecystitis were divided into control group and experimental group according to the random numerical table,with 75 cases in each group.The control group was treated with conventional treatment,and the experimental group was treated with laparoscopic cholecystectomy.Both groups were compared in terms of quality of life(QOL)score,the level of inflammation indexes[tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)]before and after treatment,incision length,operative time,intraoperative blood loss,length of hospital stay,and the incidence of complications.Results After treatment,QOL score in both groups were higher than that before treatment in this group,and TNF-α,hs-CRP and IL-6 were lower than those before treatment in this group;QOL score of(93.56±3.25)points in the experimental group was higher than that of(83.12±3.03)points in the control group;the experimental group had TNF-α of(1.51±0.21)ng/ml,hs-CRP of(7.12±1.02)mg/L,and IL-6 of(61.13±2.16)pg/ml,which were lower than those of(2.41±0.28)ng/ml,(9.25±1.56)mg/L,and(121.21±2.11)pg/ml in the control group;the differences were statistically significant(P<0.05).In the experimental group,the incision length was(2.92±0.62)cm,the operative time was(41.02±8.92)min and the length of hospital stay was(4.12±1.52)d,which were shorter than those of(9.72±3.22)cm,(68.33±10.32)min and(9.33±2.62)d in the control group;the intraoperative blood loss of(30.42±2.32)ml in the experimental group was less than that of(75.33±10.64)ml in the control group;the differences were statistically significant(P<0.05).The complication rate of the experimental group was 2.67%,which was lower than that of 13.33% of the control group,and the difference was statistically significant(P<0.05).Conclusion Laparoscopic cholecystectomy is effective in the treatment of patients with acute cholecystitis,which can effectively control the body inflammation.Compared with open surgery,it has shorter incision,less blood loss and fewer complications,which is conducive to improve the quality of life of patients after operation.
作者
马青野
MA Qing-ye(The Fourth People's Hospital of Zhangwu County,Fuxin 123200,China)
出处
《中国现代药物应用》
2023年第18期48-51,共4页
Chinese Journal of Modern Drug Application
