摘要
为防止植入体细菌感染,通过水热法在钛种植体表面制备石墨烯量子点掺杂的TiO_(2)纳米棒阵列。采用扫描电子显微镜、高分辨透射电子显微镜、原子力显微镜、X射线光电子能谱仪、X射线衍射仪和傅里叶转换红外光谱仪对纳米棒阵列进行表征,证明石墨烯量子点被成功掺杂到TiO_(2)纳米棒表面,纳米棒平均直径为60 nm,且纳米棒阵列的亲水性能得到明显改善。由于石墨烯量子点与纳米棒结构的协同作用,掺杂纳米棒阵列对变异链球菌表现出优良的抗菌能力,其抗菌率为97.8%。此外,掺杂纳米阵列还具有良好的生物相容性及成骨性能,在感染模型下依然可以促进新骨生成。
Graphene quantum dots(GQDs)were incorporated into TiO_(2) nanorods(TiO_(2) NR)by hydrothermal treatment to prevent bacterial infections of Ti implants.The successful preparation of TiO_(2) NR doped with GQDs on Ti was confirmed by scanning electron microscopy,high-resolution transmission electron microscopy,atomic force microscopy,X-ray photoelectron spectroscopy,X-ray diffraction and Fourier transform infrared spectrometer.Results showed that the mean diameter of the nanorod was 60 nm,and the hydrophilicity was significantly improved.The GQDs-modified TiO_(2) NR showed excellent antimicrobial effect against Streptococcus mutans with an efficiency of 97.8%due to the combined effect of GQDs and nanorod structure.Moreover,GQDs-modified TiO_(2) NR exhibited good biocompatibility and osteogenetic potency for cell spreading,thus contributing to the new bone formation even in bacteria-induced implant infection.
作者
张翔宇
鲁舒心
赫东梅
柴茂洲
武壮壮
姚晓红
杨永强
Xiang-yu ZHANG;Shu-xin LU;Dong-mei HE;Mao-zhou CHAI;Zhuang-zhuang WU;Xiao-hong YAO;Yong-qiang YANG(College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China;Shanxi Key Laboratory of Biomedical Metal Materials,College of Materials Science and Engineering,Taiyuan University of Technology,Taiyuan 030024,China;Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair,Department of Orthopedics,Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Special Equipment Safety Supervision Inspection Institute of Jiangsu Province,National Graphene Products Quality Inspection and Testing Center(Jiangsu),Wuxi 214174,China)
基金
financially supported by the National Natural Science Foundation of China(Nos.52171240,81902273)
the Postdoctoral Science Foundation of China(No.2021M691992)
the Major Projects in Research and Development of Shanxi Province,China(Projects of International Cooperation,No.201803D421090)
the Natural Science Foundation of Special Equipment Safety Supervision Inspection Institute of Jiangsu Province,China(No.KJ(Y)2020037)。
关键词
石墨烯量子点
纳米棒
钛
抗菌性能
骨整合
graphene quantum dots
nanorod
titanium
antibacterial property
osseointegration
作者简介
Corresponding author:Xiang-yu ZHANG,E-mail:zhangxiangyu@tyut.edu.cn;Yong-qiang YANG,E-mail:yyqyyq_2008@163.com。
