摘要
良好的精子活力是男性保持生育力的关键。线粒体是精子活力的主要调节器,当精子线粒体DNA损伤、线粒体蛋白表达异常、线粒体膜电位改变、氧化应激损伤时,精子活力均明显降低,导致男性不育。白藜芦醇是植物多酚类化合物中抗氧化能力最强的物质之一,具有清除氧自由基、抑制脂质过氧化、调节相关酶活性及基因表达等作用。本文对白藜芦醇在精子线粒体损伤导致的男性不育中的潜在作用和相关机制进行综述,为男性不育的临床治疗与相关研究提供参考依据。
Good sperm motility is the key for men to maintain fertility.Mitochondria are the main regulator of sperm motility.When sperm mitochondrial DNA is damaged,mitochondrial protein expression is abnormal,mitochondrial membrane potential changes,oxidative stress damage,sperm motility is significantly reduced,leading to male infertility.Resveratrol is one of the most powerful antioxidants substances in plant polyphenols.It has the functions of scavenging oxygen free radicals,inhibiting lipid peroxidation,regulating the activity of related enzymes and gene expression.This article reviews the potential role and related mechanism of resveratrol in male infertility caused by sperm mitochondrial damage,and provides a reference for the clinical treatment and related research of male infertility.
作者
石拴霞
王纪田
魏璐晓
宋诚
阎一鑫
王玲
SHI Shuanxia;WANG Jitian;WEI Luxiao;SONG Cheng;YAN Yixin;WANG Ling(Reproductive Medicine Center,940 Hospital of the Joint Logistics Support Force of the People′s Liberation Army of China,Lanzhou730050,Gansu,China;No.1 School of Clinical Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou730000,Gansu,China)
出处
《中国性科学》
2023年第9期5-9,共5页
Chinese Journal of Human Sexuality
基金
甘肃省青年科技基金计划(21JR1RA188)
军队后勤科研计生专项课题(20JSZ09)。
关键词
白藜芦醇
精子
线粒体损伤
氧化应激
男性不育
Resveratrol
Sperm
Mitochondrial damage
Oxidative stress
Male infertility
作者简介
通讯作者:王玲,E-mail:szyxzx2020@163.com。
