摘要
近年来,2型糖尿病(T2DM)的发病率逐渐增高。研究表明,肠黏膜屏障损伤与T2DM的发生发展关系密切,肠黏膜屏障是肠道内容物与机体血液循环之间的重要屏障,包括免疫屏障、机械屏障、化学屏障和生物屏障,各种肠黏膜屏障损伤过程中均存在肠道炎症反应,肠道炎症反应也是肠黏膜屏障损伤导致T2DM的关键因素。“燥热怫郁”理论是中医消渴病诊疗理论的重要组成部分,由刘完素在《三消论》中首先提出,并应用于临床实践。饮食不节、脾胃亏虚为致病之本,而脾胃虚弱与肠道消化吸收及黏膜屏障功能损伤密切相关。燥热内生、腠理怫郁是消渴病的关键病机,中医学燥热内生的病机演变颇切合西医学慢性炎症反应的病理特点,肠道腠理的作用与西医学肠黏膜屏障功能相吻合。因此,基于“燥热怫郁”理论探讨肠黏膜屏障损伤与T2DM的关系,可为中医学论治T2DM提供理论依据。
In recent years,the incidence of diabetes mellitus type 2(T2DM)has gradually increased.Studies have shown that intestinal mucosal barrier injury is closely related to the occurrence and development of T2DM.The intestinal mucosal barrier is an important barrier between intestinal contents and the body's blood circulation,including the immune barrier,the mechanical barrier,the chemical barrier,and the biological barrier.Intestinal inflammatory reactions take place in various processes of intestinal mucosal barrier injury,which is also a key factor in T2DM-induced intestinal mucosal barrier injury.As an important part of the traditional Chinese medicine diagnosis and treatment theory of emaciation-thirst disease,“dryness-heat and stagnation”was first proposed and applied in clinical practice in Liu Wansu’s San Xiao Lun.Improper diet and deficiency of the spleen and stomach are the root causes of the disease,and the weakness of the spleen and stomach is closely related to intestinal digestion and absorption and reduced mucosal barrier function.The endogenous dryness-heat and stagnation of striae and interstices is the key pathogenesis of emaciation-thirst.The evolution of pathogenesis of endogenous dryness-heat in traditional Chinese medicine is quite consistent with the pathological characteristics of a chronic inflammatory response in western medicine.The action of striae and interstices of the intestine is consistent with the function of the intestinal mucosal barrier in western medicine.Therefore,the relationship between intestinal mucosal barrier injury and T2DM is discussed based on“dryness-heat and stagnation”theory,which will provide a theoretical basis for the treatment of T2DM.
作者
李嘉鑫
王庆峰
安继仁
杨宇峰
石岩
LI Jiaxin;WANG Qingfeng;AN Jiren;YANG Yufeng;SHI Yan(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2023年第7期992-998,共7页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家重点基础研究发展计划项目(No.2013CB532004)
辽宁省自然科学基金重点项目(No.20170540598)
辽宁省“百千万人才工程”资助项目(No.2020921039)
辽宁省“兴辽英才计划”青年拔尖人才资助项目(No.XLYC1807145)。
关键词
燥热怫郁
肠黏膜屏障损伤
2型糖尿病
炎症反应
dryness-heat and stagnation
intestinal mucosal barrier injury
diabetes mellitus type 2
inflammatory response
作者简介
李嘉鑫,女,在读博士生;通信作者:杨宇峰,男,博士,教授,硕士生导师,主要研究方向:中西医结合防治糖尿病及代谢综合征,E-mail:yyf701@163.com。
