摘要
目的探究血清可溶性血管内皮生长因子受体1(soluble vascular endothelial growth factor receptor-1,sFLT1)、C1q/肿瘤坏死因子相关蛋白3(C1q/tumor necrosis factor related protein 3,CTRP3)与子宫内膜异位症(endometriosis,EMT)的相关性。方法回顾性分析江西省景德镇市妇幼保健院收治的80例EMT患者(EMT组),依据r-AFS分期分为Ⅰ-Ⅱ期43例,Ⅲ-Ⅳ期37例,按痛经程度分为轻度46例,中-重度34例;对照组为同时间段健康体检女性80例;检测并分析两组血清sFLT1、CTRP3水平,多因素logistic回归分析Ⅲ-Ⅳ期EMT影响因素,受试者工作特征曲线(receiver operating characteristic curve,ROC)评价血清s FLT1、CTRP3对Ⅲ-Ⅳ期EMT诊断价值。结果EMT组患者血清sFLT1、CTRP3水平低于对照组(P<0.05);中-重度痛经者血清sFLT1、CTRP3水平低于轻度者(P<0.05);r-AFS分期Ⅲ-Ⅳ期患者血清sFLT1、CTRP3水平低于Ⅰ-Ⅱ期者(P<0.05);EMT患者血清sFLT1、CTRP3分别与r-AFS分期、痛经程度呈负相关(P<0.05)。回归分析显示,sFLT1、CTRP3是Ⅲ-Ⅳ期EMT影响因素(P<0.05);血清sFLT1、CTRP3及联合诊断Ⅲ-Ⅳ期EMT的AUC为0.811、0.832、0.931,联合诊断效能优于sFLT1、CTRP3单独诊断。结论EMT患者血清sFLT1、CTRP3水平均降低,与痛经程度、r-AFS分期相关,是Ⅲ-Ⅳ期EMT影响因素,二者联合可辅助评估r-AFS分期。
Objective To explore the association of endometriosis(EMT)with serum soluble vascular endothelial growth factor receptor-1(sFLT1)and C1q/tumor necrosis factor related protein 3(CTRP3).Methods A retrospective analysis was conducted on 80 EMT patients(EMT group)admitted to Jingdezhen Maternal and Child Health Hospital.According to r-AFS staging,43 patients were diagnosed as stage Ⅰ-Ⅱ and 37 as stage Ⅲ-Ⅳ.According to the degree of dysmenorrhea,46 patients were classified as mild and 34 as moderate to severe.The control group consisted of 80 women receiving physical examinations during the same period of time.Serum levels of sFLT1 and CTRP3 were detected and analyzed in both groups The influencing factors of EMT in stage Ⅲ to Ⅳ were analyzed by multivariate logistic regression.The receiver operating characteristic curve(ROC)was applied to evaluate the diagnostic value of serum sFLT1 and CTRP3 for stage Ⅲ-Ⅳ EMT.Results Serum levels of sFLT1 and CTRP3 in the EMT group were lower than those in the control group(P<0.05),serum sFLT1 and CTRP3 levels in moderate to severe dysmenorrhea patients were lower than those in mild dysmenorrhea patients(P<0.05),and serum sFLT1 and CTRP3 levels in r-AFS stage Ⅲ to Ⅳ were lower than those in stage Ⅰ to Ⅱ(P<0.05).Correlation analysis showed that serum sFLT1 and CTRP3 in EMT patients were negatively correlated with r-AFS staging and degree of dysmenorrhea(P<0.05),respectively.Regression analysis showed that sFLT1 and CTRP3 were the influencing factors for stage Ⅲ-Ⅳ EMT(P<0.05).The AUC values of serum sFLT1 and CTRP3 in combination with diagnosis of stage Ⅲ-Ⅳ EMT were 0.811,0.832,and 0.931,respectively;the combined diagnostic efficacy was better than that of sFLT1 and CTRP3 alone.Conclusions Serum levels of sFLT1 and CTRP3 decrease in EMT patients,which are related to the degree of dysmenorrhea and r-AFS staging and are influencing factors for stage Ⅲ-Ⅳ EMT.sFLT1 combined with CTRP3 is helpful in the assessment of r-AFS stage.
作者
吴玉良
吴春玲
吴丹
WU Yuliang;WU Chunling;WU Dan(Department of Gynaecology and Obstetrics,Jingdezhen City Maternal and Child Health Care Hospital,Jingdezhen 333000,China)
出处
《实用医学杂志》
CAS
北大核心
2023年第14期1798-1803,共6页
The Journal of Practical Medicine
基金
江西省卫生健康委员会科技计划项目(编号:20204361)。
