摘要
行为变异型额颞叶痴呆(bvFTD)是一种严重的神经退行性疾病,主要表现为人格、社会行为及执行功能改变,其早期诊断和治疗仍存在挑战。MRI作为一种无创成像技术,在bvFTD的诊断和疾病进展监测中发挥关键作用。近年来,结构MRI发现bvFTD患者大脑灰质体积减小,尤其在前颞叶和前扣带回区域。此外,扩散张量成像提供了有关大脑白质微结构的信息,能显示出bvFTD患者的白质病变。动脉自旋标记技术可无创测量bvFTD患者额颞叶脑区血流灌注减低。功能MRI研究表明,bvFTD患者的大脑网络连接性发生改变。本文对目前bvFTD多模态MRI的研究进展进行综述,为其早诊、早治提供新的策略。
Behavioral variant of frontotemporal dementia(bvFTD) is a severe neurodegenerative disease mainly manifested by changes in personality,social behavior and executive function,its early diagnosis and treatment are still challenging.As a noninvasive imaging technique,MRI plays a key role in the diagnosis of bvFTD and the monitoring of disease progression.In recent years,structural MRI has revealed reduced brain gray matter volume in bvFTD patients,especially in the anterior temporal and anterior cingulate regions.In addition,diffusion tensor imaging provides information on the microarchitecture of the brain's white matter and can reveal white matter lesions in patients with bvFTD.Arterial spin labeling can non-invasively measure the decreased blood perfusion in the frontotemporal brain regions of bvFTD patients.Functional MRI studies have shown altered brain network connectivity in patients with bvFTD.This article reviews the current research progress of multimodal MRI in bvFTD and provides a new strategy for its early diagnosis and treatment.
作者
毕晟
闫少珍
卢洁
BI Sheng;YAN Shaozhen;LU Jie(Department of Radiology and Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics,Key Laboratory of Neurodegenerative Diseases,Ministry of Education,Beijing 100053,China)
出处
《中国医学影像学杂志》
CSCD
北大核心
2023年第8期887-891,共5页
Chinese Journal of Medical Imaging
基金
国家自然青年科学基金(82102010)。
关键词
额颞叶痴呆
运动神经元病
行为障碍
磁共振成像
综述
Frontotemporal dementia
Motor neuron disease
Conduct disorder
Magnetic resonance imaging
Review
作者简介
通信作者:卢洁.imaginglu@hotmail.com。
