摘要
目的研究基线全血细胞计数参数(白细胞计数、红细胞分布宽度、血小板参数)与尘肺患者肺动脉高压发病风险的关联。方法本研究是一项回顾性队列研究,收集2012年1月至2021年11月四川省某职业病医院尘肺住院患者病历资料,通过Cox比例风险回归分析探索白细胞计数、红细胞分布宽度、血小板参数与尘肺患者肺动脉高压发病风险的关联,其他全血细胞计数参数由于数据缺失未纳入分析。结果共有896名尘肺患者被纳入研究,随访期间共有202名患者发生肺动脉高压。多因素Cox比例风险回归分析显示,基线时红细胞分布宽度(HR=1.53,95%CI:1.14~2.05),血小板计数(HR=1.48,95%CI:1.11~1.98)和血小板压积(HR=1.34,95%CI:1.00~1.80)高于中位数的尘肺患者发生肺动脉高压的风险更高。结论基线较高的红细胞分布宽度、血小板计数和血小板压积与尘肺患者的肺动脉高压发病风险较高有关。
Objective To investigate the association between baseline complete blood count parameters(white blood cell count,red blood cell distribution width,and platelet parameters)and the risk of incident pulmonary hypertension in pneumoconiosis patients.Methods This was a retrospective cohort study.The medical records of pneumoconiosis inpatients in an occupational disease hospital in Sichuan Province from January 2012 to November 2021 were collected.The Cox proportional hazard regression models were used to assess the association of white blood cell count,red blood cell distribution width,and platelet parameters with the risk of incident pulmonary hypertension in pneumoconiosis,other complete blood count parameters were not included in the analysis due to data missing.Results A total of 896 pneumoconiosis patients were included in the study,and 202 patients developed pulmonary hypertension during the follow-up period.Multivariate Cox proportional risk regression analysis showed that red blood cell distribution width(HR=1.53,95%CI:1.14-2.05),platelet count(HR=1.48,95%CI:1.11-1.98),and plateletcrit(HR=1.34,95%CI:1.00-1.80)above the median at baseline had a higher risk of pulmonary hypertension in pneumoconiosis.Conclusion Higher red blood cell distribution width,platelet count and plateletcrit at baseline are associated with higher risk of incident pulmonary hypertension in pneumoconiosis patients.
作者
刘丽芳
彭姗姗
喻文鳌
魏宇豪
何秋蓉
史莹
杜文
陈荔
韩俗
彭莉君
谢林伸
姜侠
兰亚佳
姚于勤
张本
伍东升
LIU Li-fang;PENG Shan-shan;YU Wen-ao;WEI Yu-hao;HE Qiu-rong;SHI Ying;DU Wen;CHEN Li;HAN Su;PENG Li-jun;XIE Lin-shen;JIANG Xia;LAN Ya-jia;YAO Yu-qin;ZHANG Ben;WU Dong-sheng(West China Occupational Pneumoconiosis Cohort Study(WCOPCS)workgroup,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu,Sichuan 610041,China)
出处
《现代预防医学》
CAS
北大核心
2023年第16期2916-2920,2925,共6页
Modern Preventive Medicine
基金
国家自然科学基金区域创新发展联合基金项目(U22A20359)
四川省科技厅自然科学基金项目(2023NSFSC0647,2023NSFSC1729,2023NSFSC0649)。
关键词
尘肺
肺动脉高压
白细胞计数
红细胞分布宽度
血小板
Pneumoconiosis
Pulmonary hypertension
White blood cell count
Red blood cell distribution width
Platelet
作者简介
刘丽芳(1998-),女,硕士在读,研究方向:流行病学;通信作者:伍东升,E-mail:wdshxsy@163.com。
