摘要
Liver fibrosis is a necessary stage in the progression of chronic liver disease to cirrhosis.So far,no satisfactory drugs have been found to intervene in liver fibrosis.Liver microcirculation disorders are one of the important pathogenesis of chronic liver disease,and hepatic sinusoidal endothelial cells(HSECs)are the main cells that constitute the liver microcirculation barrier.In clinical practice,W-P bodies have been detected in HSECs of most patients with liver fibrosis.W-P bodies serve as a site for the synthesis and storage of vW factors,ET-1 and other cytokines that promote liver fibrosis.They can disrupt the structure and function of HSECs,cause liver microcirculation disorders,and exacerbate the progression of liver fibrosis.Previous studies have found that the Guangxi specialty ethnic medicine,C.kwangsiensis S.G.Lee et C.F.Liang,has definite effects in promoting blood circulation,resolving blood stasis,and resisting liver fibrosis.Based on this,a further research idea has been derived,stating that the blood circulation-promoting,blood stasis-resolving,and anti-liver fibrosis effects of C.kwangsiensis are produced by affecting the formation of W-P bodies,the synthesis and storage of contents in W-P bodies,and intervening in their exocytosis capacity.
基金
Supported by National Natural Science Foundation of China(81960761,82060825)
Natural Science Foundation of Guangxi(2020GXNSFAA297119)
First-class Discipline in Guangxi:Traditional Chinese Medicine(GJKY[2022]1)
Guangxi Famous Traditional Chinese Medicine Doctor Linjiang Inheritance Studio(GZYYKJF[2021]6)
Guangxi Graduate Education Innovation Program(YCSY2023004,YCSZ2022002).
作者简介
Weiqian GUO(1996-),female,P.R.China,devoted to research about mechanism of traditional Chinese medicine in treating liver diseases.contributed equally to this work;Mingzhe LU(1997-),male,P.R.China,devoted to research about mechanism of traditional Chinese medicine in treating liver diseases.contributed equally to this work;Corresponding author:Yue PENG.E-mail:834908495@qq.com;Corresponding author:Jiang LIN.E-mail:834908495@qq.com.
