摘要
长链非编码RNA(lncRNA)与人类消化道癌症的发生发展高度相关。首先,lncRNA通过靶向调控下游癌症基因表达,影响癌细胞的生长、转移、凋亡、代谢和免疫逃逸等,调节消化道癌症的发生和发展。其次,lncRNA也是癌症进展中调控脂代谢的重要因子,可以调控癌细胞的脂肪生成及其相关信号通路,从而影响消化道癌症发生发展。最后,lncRNA在消化道癌症的诊断及治疗中有一定应用价值,如lncRNA MALAT1可以作为肝细胞癌诊断和治疗靶点。本文梳理并总结了近些年关于lncRNA在消化道癌症及其脂代谢中的调控作用,为消化道癌症的防治研究提供理论依据。
Long non-coding RNAs(lncRNAs)are strongly related to the occurrence and development of digestive tract cancer in human.Firstly,lncRNAs target and regulate the expression of downstream cancer genes to affect the growth,metastasis,apoptosis,metabolism and immune escape of cancer cells.Secondly,lncRNAs are considered to be important regulating factors for lipid metabolism in cancer,which is related to signaling pathways of adipogenesis and involved in the occurrence and development of digestive tract cancer.Finally,lncRNAs have application value in the diagnosis and treatment of digestive tract cancer.For example,lncRNA MALAT1 has been reported as a target for diagnosis and treatment of hepatocellular carcinoma.This article reviews current progress on the regulatory role of lncRNAs in digestive tract cancer,to provide references for the research and clinical application in the prevention and treatment of digestive tract cancer.
作者
张振东
王小平
ZHANG Zhendong;WANG Xiaoping(School of Medicine,Xizang Minzu University,Key Laboratory of High Altitude Hypoxia Environment and Life Health,Joint Laboratory for Research on Active Components and Pharmacological Mechanism of Tibetan Materia Medica of Tibetan Medical Research Center of Tibet,Xianyang 712082,Shaanxi Province,China)
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2023年第4期451-459,共9页
Journal of Zhejiang University(Medical Sciences)
基金
西藏自治区自然科学基金(XZ202101ZR0074G)
西藏民族大学重大培育计划(20MDT02)
国家级大学生创新创业训练计划支持项目(202210695033)
陕西省自然科学基金(2020JM-590,2022JM-465)。
关键词
长链非编码RNA
脂代谢
消化道癌症
信号通路
靶向治疗
综述
Long non-coding RNA
Lipid metabolism
Digestive tract cancer
Signaling pathway
Targeted therapy
Review
作者简介
第一作者:张振东,硕士研究生,主要从事肿瘤分子病理学和藏医药抗肿瘤分子机制研究,E-mail:zhangzhendong360@163.com,https://orcid.org/0009-0001-2991-9593;通信作者:王小平,教授,博士生导师,主要从事肿瘤分子病理学和藏医药抗肿瘤分子机制研究,E-mail:xpwang@xzmu.edu.cn,https://orcid.org/0000-0001-9856-4549。
