摘要
目的探究多西环素联合甲硝唑对慢性子宫内膜炎合并不孕患者氧化应激指标和免疫功能的影响。方法选取2020年9月至2021年8月本院收治的86例慢性子宫内膜炎合并不孕患者作为研究对象,随机分为对照组与观察组,每组43例。对照组予以多西环素治疗,观察组在对照组基础上联合甲硝唑治疗,比较两组氧化应激指标[丙二醛(MDA)、人活性氧自由基(ROS)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)]、免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、妊娠结局、不良反应发生情况。结果治疗前,两组MDA、ROS、SOD和GSH-Px水平比较差异无统计学意义;治疗后,两组MDA、ROS水平均低于治疗前,SOD、GSH-Px水平均高于治疗前,且观察组MDA、ROS水平均低于对照组,SOD、GSH-Px水平均高于对照组,差异有统计学意义(P<0.05)。治疗前,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)比较差异无统计学意义;治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组妊娠率高于对照组,流产率低于对照组,差异有统计学意义(P<0.05);两组未孕率、不良反应发生率比较差异无统计学意义。结论多西环素联合甲硝唑治疗慢性子宫内膜炎合并不孕患者效果确切,有利于改善患者氧化应激水平,提高免疫功能,提升妊娠率,降低流产风险,且具有较高的安全性和有效性。
Objective To explore the effect of doxycycline combined with metronidazole on oxidative stress indexs and immune function in patients with chronic endometritis complicated with infertility.Methods A total of 86 patients with chronic endometritis complicated with infertility admitted to our hospital from September 2020 to August 2021 were selected as the research subjects,and they were randomly divided into control group and observation group,with 43 cases in each group.The control group was treated with doxycycline,and the observation group was treated with metronidazole on the basis of the control group,the oxidative stress indexs(malondialdehyde[MDA],reactive oxygen species[ROS],superoxide dismutase[SOD],glutatheione peroxidase[GSH-Px]),immune function index(CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)),pregnancy outcome and adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in the levels of MDA,ROS,SOD and GSH-Px between the two groups;after treatment,the levels of MDA and ROS of the two groups were lower than those before treatment,the levels of SOD and GSH-Px were higher than those before treatment,and the levels of MDA and ROS in the observation group were lower than those in the control group,and the levels of SOD and GSH-Px were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)between the two groups;after treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)of the two groups were higher than those before treatment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).The pregnancy rate in the observation group was higher than that in the control group,and the abortion rate was lower than that in the control group,the differences were statistically significant(P<0.05);there were no significant differences in the non-pregnancy rate and the incidence of adverse reactions between the two groups.Conclusion Doxycycline combined with metronidazole is effective in the treatment of chronic endometritis complicated with infertility,it is more conducive to improve the level of oxidative stress and immune function,improve the pregnancy rate,reduce the risk of abortion,and it has high safety and effectiveness.
作者
罗琼秀
袁金兰
杨岚
LUO Qiongxiu;YUAN Jinlan;YANG Lan(Department of Reproductive Medicine,Ji'an Maternal and Child Health Care Hospital,Ji'an,Jiangxi,343000,China;Department of Obstetrics,Ji'an Maternal and Child Health Care Hospital,Ji'an,Jiangxi,343000,China)
出处
《当代医学》
2023年第16期59-62,共4页
Contemporary Medicine
基金
江西省卫生健康委科技计划项目(202212818)。
关键词
多西环素
甲硝唑
慢性子宫内膜炎
氧化应激
免疫功能
Doxycycline
Metronidazole
Chronic endometritis
Oxidative stress
Lmmune function
