摘要
目的分析糖化血红蛋白(HbAlc)、糖化血清蛋白(GSP)水平在2型糖尿病患者中的应用价值。方法选取2020年1—7月本院收治的111例2型糖尿病患者作为研究对象,均行常规对症治疗及HbAlc、GSP水平检测。分析患者血糖控制情况及空腹血糖(FBG)水平控制情况,比较不同FBG水平控制情况患者HbAlc、GSP水平,分析HbAlc、GSP水平与2型糖尿病患者FBG水平的相关性及HbAlc、GSP单独检测及联合检测对2型糖尿病患者血糖控制情况的预测价值。结果治疗1个月后,111例2型糖尿病患者中,血糖水平控制有效81例,占比72.97%,FBG水平为(5.68±0.39)mmol/L;血糖水平控制无效30例,占比27.03%,FBG水平为(7.49±0.51)mmol/L;血糖水平控制无效患者HbAlc、GSP水平均高于血糖控制有效患者,差异有统计学意义(P<0.05)。双变量Pearson直线相关性分析显示,2型糖尿病患者HbAlc、GSP水平与FBG水平均呈正相关(r>0,P<0.05)。绘制ROC曲线显示,HbAlc、GSP单独检测及联合检测对2型糖尿病患者血糖控制的AUC值分别为0.741、0.720、0.787,均有一定预测价值。结论HbAlc、GSP水平在2型糖尿病患者中的应用价值较高,HbAlc、GSP水平越高,患者的血糖水平控制效果越差,故临床可依据HbAlc、GSP水平对患者进行合理干预,以改善患者预后。
Objective To analyze the application value of glycosylated hemoglobin Alc(HbAlc)and glycosylated serum protein(GSP)levels in patients with type 2 diabetes mellitus.Methods 111 patients with type 2 diabetes mellitus admitted to our hospital from January 2020 to July 2020 were selected as the research subjects,and all of them were treated with routine symptomatic treatment and the levels of HbAlc and GSP were detected,the blood glucose control and fasting blood glucose(FBG)level control of patients were analyzed,the levels of HbAlc and GSP in patients with different FBG levels control were compared,and the correlation between HbAlc,GSP levels and FBG levels in patients with type 2 diabetes mellitus were analyzed,and the predictive value of HbAlc and GSP alone and combined detection for blood glucose control in patients with type 2 diabetes mellitus were analyzed.Results After 1 month of treatment,among 111 patients with type 2 diabetes mellitus,blood glucose level was effectively controlled in 81 cases,accounting for 72.97%,and the FBG level was(5.68±0.39)mmol/L;blood glucose level control was ineffective in 30 cases,accounting for 27.03%,and the FBG level was(7.49±0.51)mmol/L;the levels of HbAlc and GSP in patients with ineffective control of blood glucose were higher than those in patients with effective control of blood glucose,and the differences were statistically significant(P<0.05).Bivariate Pearson linear correlation analysis showed that the levels of HbAlc,GSP were positively correlated with the levels of FBG in type 2 diabetes mellitus patients(r>0,P<0.05).The ROC curve shows that the AUC values of HbAlc,GSP levels and combined detection for blood glucose control in patients with type 2 diabetes mellitus were 0.741,0.720 and 0.787,respectively,which had certain predictive value.Conclusion The application value of HbAlc and GSP levels in patients with type 2 diabetes mellitus is high,the higher levels of HbAlc and GSP,the worse the control effect of blood glucose level in patients,therefore,reasonable clinical intervention can be carried out according to the levels of HbAlc and GSP in clinical practice to improve the prognosis of patients.
作者
梅玉霞
郭海燕
余建华
MEI Yuxia;GUO Haiyan;YU Jianhua(Jiujiang Fifth People's Hospital,Jiujiang,Jiangxi,332000,China)
出处
《当代医学》
2023年第6期80-83,共4页
Contemporary Medicine
关键词
2型糖尿病
糖化血清蛋白
糖化血红蛋白
空腹血糖
Type 2 diabetes mellitus
Glycosylated serum protein
Glycosylated hemoglobin Alc
Fasting blood glucose
