摘要
目的:分析赣南地区新型冠状病毒奥密克戎变异株(SARS-CoV-2 Omicron)感染患者的临床特点与药学监护情况,为该类患者的救治提供参考。方法:选取2022年9月—10月赣州市第五人民医院收治的240例SARS-CoV-2 Omicron感染患者作为研究对象,采集患者的年龄、性别、疫苗接种、药物使用、用药干预、药物不良反应等信息,分析患者的流行病学特点。结果:240例SARS-CoV-2 Omicron感染患者的年龄主要集中在18~60岁(156例,占65.00%),临床分型主要为轻型(205例,占85.42%)和无症状(24例,占10.00%);240例患者中有228例接种过疫苗(接种率为95.00%),其中完全全程接种的有162例;用药情况分析显示,240例患者全部使用了抗病毒药物,其中使用最多的是阿兹夫定片(192例,占85.71%),其用药疗程为(13.55±2.87)d;而使用抗菌药物的仅有62例,使用率为25.83%;使用中成药的有240例(使用率为100.00%),其中使用最多的为连花清瘟颗粒(231例,占96.25%)和肺力咳合剂(127例,占52.92%);针对240例患者,临床药师累计审核医嘱9676条,其中不合理医嘱有24条(不合理率为0.25%),对此临床药师均提出了用药建议,而采纳的有21条(采纳率为87.50%);用药期间,有5例报告药物不良反应,但均不严重。结论:此次赣南地区SARS-CoV-2 Omicron感染主要表现为无症状和轻型,在临床药师的支持协助下,患者住院期间用药情况较为合理,且药物不良反应发生较少。
Objective:To analyze the clinical characteristics and pharmaceutical care of patients infected with SARSCoV-2 Omicron in southern Jiangxi,and provide reference for the treatment of such patients.Methods:240 patients infected with SARS-CoV-2 Omicron and admitted to the Fifth People's Hospital of Ganzhou City from September to October 2022 were selected as the research subjects.Information such as age,gender,vaccination,drug use,medication intervention and adverse drug reactions of the patients was collected,and the epidemiological characteristics of the patients were analyzed.Results:The 240 patients infected with SARS-CoV-2 Omicron were mainly at the age of 18 to 60(156 cases,65.00%),and the clinical classification was mainly mild(205 cases,85.42%)and asymptomatic(24 cases,10.00%).A total of 228 of the 240 patients were vaccinated(with a vaccination rate of 95.00%),of which 162 were fully vaccinated throughout the entire process.Analysis of medication status showed that all 240 patients had used antiviral drugs,with the most commonly used being Azvudine tablets(192 cases,85.71%),with a medication course of(13.55±2.87)d.Only 62 cases used antibacterial drugs,with a usage rate of 25.83%.240 cases(100.00%)used traditional Chinese patent medicines and simple preparations,of which Lianhua Qingwen Granules(231 cases,96.25%)and Feilike Mixture(127 cases,52.92%)were the most used.For the 240 patients,clinical pharmacists had reviewed a total of 9676 medical orders,of which 24 were unreasonable(with an unreasonable rate of 0.25%),and clinical pharmacists had proposed medication suggestions,while 21 were adopted(with an adoption rate of 87.50%).During the medication period,5 cases of adverse drug reactions were reported,but none were severe.Conclusion:The SARS-CoV-2 Omicron infections in southern Jiangxi this time are mainly asymptomatic and mild.With the support and assistance of clinical pharmacists,the patients have reasonable medication during hospitalization,with fewer adverse drug reactions.
作者
吴庆荣
宋晓兵
龚享文
张丽华
张宇
刘建平
WU Qing-rong;SONG Xiao-bing;GONG Xiang-wen;ZHANG Li-hua;ZHANG Yu;LIU Jian-ping(The Fifth People's Hospital of Ganzhou City,Ganzhou Jiangxi 341000,China;Ganzhou Respiratory Disease Research Institute,Ganzhou Jiangxi 341000,China)
出处
《抗感染药学》
2023年第5期475-481,共7页
Anti-infection Pharmacy
基金
江西省科技厅重点项目(编号:2020YBBGWL006)
赣州市科技局新型冠状病毒感染肺炎疫情应急科技计划项目(编号:赣市科发[2020]17号)。
作者简介
吴庆荣(1993-),男,硕士,主管药师;通信作者:刘建平(1981-),女,副主任护师,电子邮箱:13265167238@163.com。
