摘要
目的对不同单胞结构设计骨支架的研究进展进行综述。方法广泛查阅近年来国内外对于不同单胞结构设计骨支架的相关文献,总结其研究进展。结果骨支架的单胞结构可分为规则单胞结构、不规则单胞结构、基于拓扑优化理论设计的单胞结构以及基于三周期极小曲面设计的单胞结构。不同单胞结构具有不同的结构形态和几何特征,单胞结构的选择直接决定了骨支架的力学性能以及生物学性能。合理选择单胞结构对于骨支架替代原生骨组织至关重要。结论对于骨支架的研究已相当广泛,但目前骨支架种类繁多,应全面考虑优化单胞结构,有助于开发性能优良的骨支架,为骨组织的修复提供有效支撑。
Objective To review the research progress of design of bone scaffolds with different single cell structures.Methods The related literature on the study of bone scaffolds with different single cell structures at home and abroad in recent years was extensively reviewed,and the research progress was summarized.Results The single cell structure of bone scaffold can be divided into regular cell structure,irregular cell structure,cell structure designed based on topology optimization theory,and cell structure designed based on triply periodic minimal surface.Different single cell structures have different structural morphology and geometric characteristics,and the selection of single cell structure directly determines the mechanical properties and biological properties of bone scaffold.It is very important to choose a reasonable cell structure for bone scaffold to replace the original bone tissue.Conclusion Bone scaffolds have been widely studied,but there are many kinds of bone scaffolds at present,and the optimization of single cell structure should be considered comprehensively,which is helpful to develop bone scaffolds with excellent performance and provide effective support for bone tissue.
作者
孙亚迪
王岩
周丽芸
李奕扬
申佳慧
董本超
杨培川
李岩
马剑雄
马信龙
SUN Yadi;WANG Yan;ZHOU Liyun;LI Yiyang;SHEN Jiahui;DONG Benchao;YANG Peichuan;LI Yan;MA Jianxiong;MA Xinlong(Institute of Orthopaedics,Tianjin Hospital,Tianjin University(Tianjin Hospital),Tianjin,300211,P.R.China;Tianjin Orthopedic Institute,Tianjin,300050,P.R.China;Tianjin Key Laboratory of Orthopedic Biomechanics and Medical Engineering,Tianjin,300050,P.R.China)
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2023年第8期1037-1041,共5页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家重点研发计划项目(2022YFC3601904)
天津市自然科学基金重点项目(22JCZDJC00340)
天津市卫生健康科技项目(TJWJ2022QN053)。
关键词
骨支架
单胞结构
力学性能
生物学性能
Bone scaffold
single cell structure
mechanical properties
biological properties
作者简介
通信作者:马剑雄,Email:mjx969@163.com。
