摘要
目的基于正交试验法优选天钩平肝颗粒的成型工艺。方法以颗粒的成型率、溶化时间、流动性的综合得分为评价指标,采用L_(9)(3^(4))正交试验法优化药辅比、润湿剂的体积分数和用量,筛选出天钩平肝颗粒的成型工艺。结果天钩平肝颗粒的最佳药辅比为稠膏∶糊精∶淀粉=1∶1∶1(g∶g∶g),以85%乙醇作润湿剂,润湿剂用量为润湿剂∶稠膏=74∶100(mL∶g)。结论优选出的天钩平肝颗粒成型工艺重复性好,质量稳定可靠,为其大批量生产提供依据。
Objective To optimize the forming process of Tiangoupinggan granules based on orthogonal experiment.Methods The composite of particle forming rate,melting and fluidity was used as the evaluation index.The L_(9)(3^(4))orthogonal test method was used to optimize the drug-assisted ratio,the volume fraction and dosage of wetting agent,and the molding process of Tiangoupinggan granules was screened.Results The optimum molding process of Tiangou pinggan granules was thick paste:dextrin:dextrin:starch=1∶1∶1(g∶g∶g),85%ethanol as wetting agent,dosage of wetting agent was wetting agent∶thick paste=74∶100(mL∶g).Conclusions The quality of Tiangoupinggan granules prepared by the optimized forming process is stable and reliable with good repeatability,which provides the basis for its mass production.
作者
何清华
钟佰明
范润勇
张明
HE Qinghua;ZHONG Baiming;FAN Runyong;ZHANG Ming(Pharmacy Department of Nanchong Hospital of Traditional Chinese Medicineof Sichuan Province,Nanchong Sichuan 637000,China)
出处
《云南医药》
CAS
2023年第4期65-68,共4页
Medicine and Pharmacy of Yunnan
基金
四川省科技厅重点研发项目(2020YFS0528)
四川省中医药管理局项目(2020CP0018)
南充市科技局计划项目(20YFZJ0069)
南充市科技局计划项目(20YFZJ0066)。
关键词
天钩平肝颗粒
成型工艺
正交试验
Tiangoupinggan granules
forming process
orthogonal experiment
作者简介
何清华(1979-)女,本科,主管中药师,从事中药制剂工艺研究工作25余年;通信作者:张明,E-mail:309823443@qq.com。
