摘要
Developing a phototherapy modality to ablate tumor and then trigger immunogenic cell death(ICD)for simultaneously eliminating distal and metastatic tumors holds great promise in clinical applications.Herein,the polyethylene glycol functionalized Ni_(2)P(Ni_(2)P@PEG NPs)is developed with enhanced biocompatibility,high photoabsorption and photothermal efficiency,as well as reactive oxygen species generation ability.Of particular note,Ni_(2)P@PEG NPs mediated phototherapy could not only realize efficient ablation of primary tumors,but also inhibit distal tumors and metastatic tumors by triggering an antitumor immune response.The above conclusions were verified by B mode ultrasound,western blot assay,and immunohistochemistry analysis.Meanwhile,Ni_(2)P@PEG NPs showed excellent magnetic resonance imaging(MRI)properties.In summary,the MRI-guided multimodal cancer therapies of Ni_(2)P@PEG NPs represent significant potential for clinical applications.
基金
supported by the National Science Foundation of Heilongjiang Province(No.LH2019E046)
the Heilongjiang Provincial Postdoctoral Starting Foundation(No.LBHQ19016).
作者简介
Corresponding authors:Huike Yang.E-mail addresses:huikeyang@hrbmu.edu.cn;Corresponding authors:Chongshen Guo,chongshenguo@hit.edu.cn。
