摘要
骨质疏松症(osteoporosis, OP)是骨吸收大于骨形成的骨代谢疾病,随着全球老龄化加重,严重威胁人类健康安全。续断作为传统补肾中药在防治OP方面具有广阔潜力,有关研究表明续断通过多靶点、多途径调控相关信号通路防治OP。最新药理学研究证明续断提取物木通皂苷D等成分可通过调控有关信号通路和促炎因子干预碱性磷酸酶、骨保护蛋白、骨钙素等蛋白因子表达,作用于成骨细胞、破骨细胞以及骨髓间充质干细胞有效防治OP。通过检索续断提取物防治OP的基础研究发现,续断提取物木通皂苷D、熊果酸、多糖类可以通过Wnt/β-catenin、MAPK、PI3K/AKT、BMP-Smads信号通路促骨形成,通过OPG/RANKL/RANK、雌激素信号通路抑制骨吸收防治OP。笔者就续断提取物调控不同信号通路,促进成骨细胞增殖,抑制破骨细胞分化,诱导骨髓间充质干细胞定向分化作一综述,为今后中医药防治OP的基础研究提供新思路。
Osteoporosis(OP)is a bone metabolic disease in which bone resorption is over bone formation.With the increase of global aging,it seriously threatens human health and safety.Dipsacus,as a traditional kidney-tonifying traditional Chinese medicine,has great potential in the prevention and treatment of OP.Relevant studies have shown that dipsacus prevents and treats OP through multi-target and multi-channel regulation of related signaling pathways.The latest pharmacological studies have proved that ingredients such as aketoside D of dipsacus extract intervenes with the expression of alkaline phosphatase,osteoprotegerin,osteocalcin,and other protein factors by regulating related signaling pathways and pro-inflammatory factors,and acts on osteoblasts,osteoclasts,etc.Bone cells and bone marrow mesenchymal stem cells effectively prevent and treat OP.By searching the basic research on the prevention and treatment of OP with dipsacus extract,it has been found that akebia saponin D,ursolic acid,and polysaccharides of dipsacus extract promote bone formation through Wnt/β-catenin,MAPK,PI3K/AKT,and BMP-Smads signaling pathways.OPG/RANKL/RANK and estrogen signaling pathways inhibit bone resorption to prevent and treat OP.The authors review how dipsacus extract regulates different signaling pathways,promotes osteoblast proliferation,inhibits osteoclast differentiation,and induces bone marrow mesenchymal stem cell directional differentiation,so as to provide new ideas for the basic research of traditional Chinese medicine in the prevention and treatment of OP in the future.
作者
金芳全
樊成虎
唐晓栋
陈彦同
齐兵献
胡星荣
JIN Fangquan;FAN Chenghu;TANG Xiaodong;CHEN Yantong;QI Bingxian;HU Xingrong(Gansu University of Traditional Chinese Medicine,Lanzhou 730030;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2023年第7期1016-1020,共5页
Chinese Journal of Osteoporosis
基金
国家自然科学基金(81760877)
甘肃省自然科学基金(22JR5RA640)。
关键词
中医中药
骨质疏松症
续断
木通皂苷D
骨髓间充质干细胞
信号通路
traditional Chinese medicine
osteoporosis
dipsacus
barrel saponin D
bone marrow mesenchymal stem cells
signal pathway
作者简介
通信作者:樊成虎,Email:FCH0203@163.com。
