摘要
目的探讨孟鲁司特钠联合布地奈德治疗儿童哮喘的应用效果。方法100例哮喘患儿,根据入院先后顺序分为观察组与对照组,每组50例。对照组患儿采用布地奈德治疗,观察组患儿采用孟鲁司特钠联合布地奈德治疗。比较两组患儿治疗后症状消失时间、血气指标、肺功能指标及临床疗效。结果观察组患儿治疗后胸闷消失时间、喘息消失时间、咳嗽消失时间、呼吸困难消失时间及呼吸急促消失时间分别为(1.62±0.85)、(1.14±0.53)、(3.52±0.43)、(1.62±0.81)、(1.53±0.56)d,均明显短于对照组的(3.22±1.04)、(3.25±0.56)、(5.91±1.25)、(3.89±0.22)、(3.89±0.69)d,差异有统计学意义(P<0.05)。观察组患儿治疗总有效率96.0%明显高于对照组的74.0%,差异有统计学意义(P<0.05)。观察组患儿二氧化碳分压为(6.44±1.45)kPa,血氧分压为(12.34±2.05)kPa,最大呼气流量占预计值百分比为(74.04±3.56)%、用力肺活量占预计值百分比为(76.55±7.14)%;对照组患儿二氧化碳分压为(8.13±1.24)kPa,血氧分压为(10.22±1.56)kPa,最大呼气流量占预计值百分比为(63.75±4.63)%,用力肺活量占预计值百分比为(67.54±5.47)%。观察组患儿二氧化碳分压低于对照组,血氧分压、最大呼气流量占预计值百分比、用力肺活量占预计值百分比均高于对照组,差异有统计学意义(P<0.05)。结论孟鲁司特钠联合布地奈德治疗儿童哮喘的临床应用效果显著,值得推广。
Objective To discuss the application effect of montelukast sodium combined with budesonide in the treatment of children with asthma.Methods A total of 100 children with asthma were divided into the observation group and the control group according to the order of their admission to the hospital,with 50 cases in each group.Children in the control group were treated with budesonide,and children in the observation group were treated with montelukast sodium and budesonide.The time to disappearance of symptoms,blood gas index,lung function index,and clinical efficacy were compared between the two groups after treatment.Results After treatment,the time to disappearance of chest tightness,wheezing,cough,dyspnea and shortness of breath were(1.62±0.85),(1.14±0.53),(3.52±0.43),(1.62±0.81)and(1.53±0.56)d in the observation group,which were significantly shorter than those of(3.22±1.04)(3.25±0.56),(5.91±1.25),(3.89±0.22)and(3.89±0.69)d in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment was 96.0%in the observation group,which was significantly higher than that of 74.0%in the control group,and the difference was statistically significant(P<0.05).In the observation group,the partial pressure of carbon dioxide was(6.44±1.45)kPa,the partial pressure of blood oxygen was(12.34±2.05)kPa,the percentage of peak expiratory flow to the predicted value was(74.04±3.56)%and the percentage of forced vital capacity was(76.55±7.14)%;in the control group,the partial pressure of carbon dioxide was(8.13±1.24)kPa,the partial pressure of blood oxygen was(10.22±1.56)kPa,the percentage of peak expiratory flow to the predicted value was(63.75±4.63)%,and the percentage of forced vital capacity was(67.54±5.47)%.The partial pressure of carbon dioxide in the observation group was lower than that in the control group,and the blood partial pressureof oxygen,percentage of peak expiratory flow and forced vital capacity were all higher than those in the control group;the differences were statistically significant(P<0.05).Conclusion The clinical effect of montelukast sodium combined with budesonide in the treatment of childhood asthma is obvious,and it is worth popularizing.
作者
路小丽
LU Xiao-li(Junan County Hospital of Traditional Chinese Medicine,Linyi 276600,China)
出处
《中国实用医药》
2023年第14期109-112,共4页
China Practical Medicine
关键词
孟鲁司特钠
布地奈德
哮喘
肺功能
儿童
Montelukast sodium
Budesonide
Asthma
Lung function
Children
