摘要
目的分析经皮肾镜联合输尿管软镜钬激光碎石术治疗难治性肾结石的临床效果。方法64例难治性肾结石患者,随机分为对照组和实验组,每组32例。实验组采用经皮肾镜联合输尿管软镜钬激光碎石术治疗,对照组采用经皮肾镜钬激光碎石术治疗。对比两组患者手术前后肾功能指标、围手术期指标。结果术后,两组患者血清肌酐、尿素氮以及β_(2)-微球蛋白水平均低于本组术前,且实验组患者血清肌酐(84.68±4.58)μmol/L、尿素氮(6.29±0.27)mmol/L、β_(2)-微球蛋白(3.46±0.23)mg/L均低于对照组的(96.23±4.69)μmol/L、(8.26±0.92)mmol/L、(4.33±0.54)mg/L,差异具有统计学意义(P<0.05)。实验组患者术中出血量(131.28±11.59)ml少于对照组的(142.49±12.24)ml,手术时间(115.09±9.58)min、住院时间(9.48±1.36)d短于对照组的(124.31±9.60)min、(6.19±1.27)d,一期结石清除率93.75%高于对照组的71.88%,差异具有统计学意义(P<0.05)。结论难治性肾结石患者采用经皮肾镜联合输尿管软镜钬激光碎石治疗术具有较高的临床价值,能够减少患者的术中出血量,缩短手术时间、住院时间,提高一期结石清除率,改善肾功能指标,值得推广应用。
Objective To analyze the clinical effect of percutaneous nephrolithotomy combined with ureteroscopic holmium laser lithotripsy for refractory renal calculi.Methods A total of 64 patients with refractory renal calculi were randomly divided into control group and experimental group,with 32 cases in each group.The experimental group was treated with percutaneous nephrolithotripsy and ureteroscopic holmium laser lithotripsy,and the control group was treated with percutaneous nephrolithotripsy.The renal function indexes and perioperative indexes before and after surgery were compared between the two groups.Results After surgery,the serum creatinine,urea nitrogen andβ_(2)-microglobulin levels in both groups were lower than those before surgery in this group;the experimental group had serum creatinine of(84.68±4.58)μmol/L,urea nitrogen of(6.29±0.27)mmol/L andβ_(2)-microglobulin of(3.46±0.23)mg/L,which were lower than those of(96.23±4.69)μmol/L,(8.26±0.92)mmol/L and(4.33±0.54)mg/L in the control group;the differences were statistically significant(P<0.05).The intraoperative blood loss of(131.28±11.59)ml in the experimental group was less than that of(142.49±12.24)ml in the control group;the operative time of(115.09±9.58)min and hospital stay of(9.48±1.36)d in the experimental group were shorter than those of(124.31±9.60)min and(6.19±1.27)d in the control group;the first-stage stone clearance rate of 93.75%in the experimental group was higher than that of 71.88%in the control group;the differences were statistically significant(P<0.05).Conclusion Percutaneous nephrolithotomy combined with ureteroscopic holmium laser lithotripsy for refractory renal calculi has high clinical value,which can reduce intraoperative blood loss,shorten operative time and hospital stay,improve the first-stage stone clearance rate and improve renal function indicators,and is worthy of promotion and application.
作者
吴春志
李嘉健
陈结能
WU Chun-zhi;LI Jia-jian;CHEN Jie-neng(Department of Urology,Taishan People's Hospital,Taishan 529200,China)
出处
《中国现代药物应用》
2023年第13期48-51,共4页
Chinese Journal of Modern Drug Application
关键词
难治性肾结石
钬激光碎石术
经皮肾镜
输尿管软镜
临床效果
Refractory renal calculi
Holmium laser lithotripsy
Percutaneous nephrolithotomy
Ureteroscope
Clinical effects
