摘要
随着富血小板血浆(platelet-rich plasma,PRP)基础研究的日益深入和临床应用的逐渐广泛,目前PRP已应用于骨科、烧伤整形科、疼痛科及生殖医学科等多种学科。近年来,PRP在促进组织修复方面已逐步得到公认,不仅能促进骨折愈合和软组织损伤修复,还具有减轻伤口疼痛、减少创面并发症发生等特点。除此之外,PRP独特的抑菌作用也成为目前研究的热点之一,然而其抗菌谱及潜在的抑菌机制尚不明确。本文就PRP的体内外抑菌作用及潜在的抑菌机制进行综述,以期为PRP用于临床抗感染治疗提供理论依据。
With the deepening study and the widening clinical application of platelet-rich plasma(PRP),it has been applied in various disciplines such as orthopedics,burn orthopedics,pain medicine and reproductive medicine.In recent years,PRP has been gradually recognized for its ability to promote tissue repair,not only for fracture healing and soft tissue injury repair,but also for reducing wound pain and trauma complications.In addition,the antibacterial effect of PRP has also become one of the hot spots of current research,however,its antibacterial spectrum and potential antibacterial mechanism are still unclear.In this paper,we reviewed the antibacterial effects of PRP in vitro and in vivo and its potential antibacterial mechanisms,in order to provide a theoretical basis for the use of PRP in clinical anti-infective therapy.
作者
刘炎
何颖雨
刘磊
郑山根
刘万兵
LIU Yan;HE Yingyu;LIU Lei;ZHENG Shangen;LIU Wanbing(Department of Transfusion Medicine,General Hospital of Central Theater Command,Wuhan,430070,China;The First School of Clinical Medicine,Southern Medical University)
出处
《临床血液学杂志》
2023年第6期452-456,共5页
Journal of Clinical Hematology
基金
国家自然科学基金(No:81801984)。
关键词
富血小板血浆
抑菌作用
抗菌谱
抑菌机制
platelet-rich plasma
antibacterial effect
antibacterial spectrum
antibacterial mechanism
作者简介
通讯作者:刘万兵,E-mail:wanbing1203x@163.com。
