摘要
糖尿病肾病(DN)是导致终末期肾脏病的重要原因之一。代谢记忆学说背景下,晚期糖基化终末产物沉积于肾脏,导致疾病移时后发、迁延难愈与中医邪伏膜原理论相吻合。现基于邪伏膜原学说,提出DN气阴不足、气化不利、痰瘀互结、邪伏膜原的病机。治疗方面,在透达膜原的基础上,重视三焦的畅通。从邪伏膜原角度论治DN,扩展了邪伏膜原学说的应用范畴,开拓了中医药治疗DN的新思路。
Diabetic nephropathy(DN)is one of the important causes of end-stage renal disease.In the context of the metabolic memory theory,advanced glycation end products(AGEs)deposit in the kidneys,leading to a delayed and difficult-to-cure progression of the disease,which coincides with the theory of latent pathogen in pleurodiaphragmatic interspace in traditional Chinese medicine(TCM).Based on the theory of latent pathogen in pleurodiaphragmatic interspace,it was proposed that the pathogenesis of DN involved insufficiency of qi and yin,impaired qi transformation,mutual obstruction of phlegm and stasis,and latent pathogen in pleurodiaphragmatic interspace.In terms of treatment,emphasis is placed on promoting the unobstructed flow of the triple energizer.In this study,DN was treated from the perspective of latent pathogen in pleurodiaphragmatic interspace.The application scope of this theory was expanded,and new ideas for the TCM treatment of DN were explored.
作者
张宗金
王悦芬
赵文景
崔方强
孟元
沈存
孙雪艳
申子龙
唐珑
李平
ZHANG Zongjin;WANG Yuefen;ZHAO Wenjing;CUI Fangqiang;MENG Yuan;SHEN Cun;SUN Xueyan;SHEN Zilong;TANG Long;LI Ping(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;China-Japan Friendship Hospital,Beijing 100029,China)
出处
《世界中医药》
CAS
2023年第11期1563-1566,共4页
World Chinese Medicine
基金
北京市自然科学基金项目(7172096)
北京市中医药科技发展资金项目(JJ-2020-46)。
关键词
膜原
邪伏膜原
糖尿病肾病
肾小球疾病
晚期糖基化终末产物
保肾方
三焦
中医药治疗
Pleurodiaphragmatic interspace
Latent pathogen in pleurodiaphragmatic interspace
Diabetic nephropathy
Glomerular disease
Advanced glycation end products
Baoshen Prescription
Triple energizer
Traditional Chinese medicine treatment
作者简介
张宗金(1996.06-),女,硕士研究生在读,研究方向:中医药防治肾脏病,E-mail:547158900@qq.com;通信作者:王悦芬(1967.12-),女,博士,主任医师,教授,研究方向:中医药防治慢性肾脏病的基础及临床研究,E-mail:85wyf@163.com。
