摘要
鞘脂代谢广泛参与不同细胞的功能调控,其在眼组织中也起重要作用。1-磷酸鞘氨醇(S1P)是鞘脂代谢的终末产物,并已经证实在眼科疾病的发生和发展中起重要的作用。S1P信号通路广泛存在于眼部各类细胞中,参与调控细胞增生、分化、迁移和凋亡等过程。S1P通过与相应受体结合激活多种信号通路,进而在眼部发挥广泛的生理及病理性作用。近年来研究发现,S1P信号通路既可以介导眼内血管和神经的正常发育、维持眼部组织正常结构和参与眼内脂质代谢,也与免疫相关炎症反应、病理性纤维化和细胞功能屏障破坏等相关病理改变有密切关系。本文主要对S1P信号通路的基本概况、眼部生理性作用以及在眼前节和眼后节疾病病理改变中的作用进行综述,为眼科疾病的治疗提供新的方向和作用靶点。
Sphingolipid metabolism is widely involved in the functional regulation of different cells,and also plays an important role in ocular tissues.Sphingosine 1-phosphate(S1P)is the end product of sphingolipid metabolism and has been shown to play an important role in the onset and development of eye diseases.S1P signaling pathway is widely expressed in various ocular cells and is involved in the regulation of cell proliferation,differentiation,migration and apoptosis.S1P activates a variety of signaling pathways by binding to corresponding receptors and thus plays a wide range of physiological and pathological effects in the eye.Recent studies have found that the S1P signaling pathway can not only mediate the normal development of blood vessels and nerves in the eye,maintain the normal structure of the ocular tissues,and participate in the metabolism of lipids in the eye,but also has a close relationship with immune-related inflammatory response,pathological fibrosis,destruction of cell functional barrier and other related pathological changes.This paper mainly reviewed the basic overview of the S1P signaling pathway,its physiological role in the eye,and its role in the pathological changes of anterior and posterior segment diseases,so as to provide new directions and targets for the treatment of eye diseases.
作者
夏敏(综述)
薛劲松
蒋沁(审校)
Xia Min;Xue Jingsong;Jiang Qin(The Affiliated Eye Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2023年第7期702-707,共6页
Chinese Journal Of Experimental Ophthalmology
基金
国家自然科学基金项目(82070983)。
作者简介
通信作者:薛劲松,Email:25068411@qq.com。
