摘要
过氧化物酶体增殖物激活受体(PPAR)是细胞核雌激素受体家族成员,参与多种体内生理病理过程,在细胞代谢、炎症及癌症等方面发挥重要作用,目前已知PPAR受体分3种亚型,分别为α、β/δ和γ。研究发现PPAR在肝脏中高度表达,广泛参与肝脏能量代谢、氧化应激、炎症等多种生理病理活动,与肝脏疾病的进展密切相关。本文就PPAR在病毒性肝炎、代谢相关脂肪性肝病、胆汁淤积性肝病、肝纤维化、原发性肝癌等常见肝脏疾病中的作用及其在肝脏疾病治疗中的应用现状作一综述。
Peroxisome proliferator-activated receptors(PPAR)are members of the nuclear estrogen receptor family,and they are involved in a variety of physiological and pathological processes in the human body and play important roles in cellular metabolism,inflammation,and cancer.At present,there are three known subtypes of PPAR,i.e.,α,β/δ,andγ.Studies have shown that PPARs are highly expressed in the liver and are widely involved in various physiological and pathological activities such as liver energy metabolism,oxidative stress,and inflammation,and they are also closely associated with the progression of liver diseases.This article reviews the role of PPAR in common liver diseases such as viral hepatitis,metabolic associated fatty liver disease,cholestatic liver disease,liver fibrosis,and primary liver cancer,and the current status of their application in the treatment of liver diseases.
作者
冯帅霞
徐莹
韩涵
FENG Shuaixia;XU Ying;HAN Han(School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2023年第7期1747-1753,共7页
Journal of Clinical Hepatology
基金
国家自然科学基金(82173946)
国家自然科学基金青年项目(82004162)
上海市自然科学基金(21ZR1460500)
上海市青年科技英才扬帆计划(20yf1449500)。
关键词
过氧化物酶体增殖物激活受体
肝疾病
炎症
Peroxisome Proliferator-Activated Receptors
Liver Diseases
Inflammation
作者简介
通信作者:韩涵,pashanhan@126.com,ORCID:0000-0001-6454-876X;通信作者:徐莹,xuying.911@163.com,ORCID:0000-0002-4645-3094。
