摘要
目的探讨阿加曲班联合丁苯酞治疗急性脑梗死的临床疗效。方法选取2019年4月至2020年4月于本院接受治疗的90例急性脑梗死患者作为研究对象,依据入院时间顺序分为对照组和观察组,每组45例。两组均给予常规治疗干预,在此基础上,对照组单纯给予丁苯酞治疗,观察组给予阿加曲班联合丁苯酞治疗。比较两组神经功能缺损情况、认知功能、凝血功能、炎症因子水平、不良用药反应发生情况及生命质量。结果治疗后,两组美国国立卫生研究院卒中量表(NIHSS)均低于治疗前,简易智力状态检查表(MMSE)评分均高于治疗前,且观察组NIHSS评分低于对照组,MMSE评分高于对照组,差异有统计学意义(P<0.05)。治疗后,两组凝血酶原时间、血浆凝血酶时间及部分凝血酶原时间均长于治疗前,纤维蛋白酶原水平低于治疗前,且观察组凝血酶原时间、血浆凝血酶时间及部分凝血酶原时间均长于对照组,纤维蛋白酶原低于对照组,差异有统计学意义(P<0.05)。治疗后,两组超敏C反应蛋白、白细胞介素-6及肿瘤坏死因子-α水平均低于治疗前,且观察组均低于对照组(P<0.05)。两组用药不良反应发生率比较差异无统计学意义。治疗后,观察组健康状态、社会功能、精神状态、生理功能评分均高于对照组(P<0.05)。结论阿加曲班联合丁苯酞治疗急性脑梗死的临床疗效较为显著,可明显改善患者神经功能缺损情况及凝血功能,提升其认知功能及生命质量,减少炎症反应,且不易出现用药不良反应,值得临床推广应用。
Objective To investigate the clinical effect of argatroban combined with butyphthalide in the treatment of acute cerebral infarction.Methods 90 patients with acute cerebral infarction who received treatment in our hospital from April 2019 to April 2020 were selected as research subjects,and they were divided into control group and observation group according to admission time sequence,with 45 cases in each group.Both groups were given conventional treatment intervention,on this basis,the control group was given butylphthalein treatment alone,and the observation group was given argatroban combined butyphthalide treatment.The neurological deficit status,cognitive function,coagulation function,inflammatory factors level,occurrence of adverse drug reactions and quality of life were compared between the two groups.Results After treatment,the National Institute of health stroke scale(NIHSS)in both groups were lower than before treatment,and the score of the mini-mental state examination(MMSE)was higher than before treatment,and the NIHSS score in the observation group was lower than the control group,and the MMSE score was higher than the control group,the difference was statistically significant(P<0.05).After treatment,the prothrombin time,plasma thrombin time and partial prothrombin time of the two groups were longer than before treatment,while the fibrinogen level was lower than before treatment,and the prothrombin time,plasma thrombin time and partial prothrombin time of the observation group were longer than that of the control group,but the fibrinogen was lower than that of the control group,with statistical significance(P<0.05).After treatment,the levels of hypersensitive C-reactive protein,interleukin-6 and tumor necrosis factor-αin two groups were lower than before treatment,and the observation group were lower than control group(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups.After treatment,the health status,social function,mental state and physiological function scores of the observation group were higher than those of the control group(P<0.05).Conclusion The clinical effect of argatroban combined with butyphthalide in treating acute cerebral infarction is relatively significant,which can significantly improve the neurological deficit and coagulation function,improve cognitive function and quality of life,reduce inflammatory reaction performance,and not easy to appear adverse drug reactions,which is worthy of clinical promotion and application.
作者
迟成
李希福
隋怡
CHI Cheng;LI Xifu;SUI Yi(Department of Neurology,Zhuanghe Central Hospital,Dalian,Liaoning,116400,China)
出处
《当代医学》
2022年第29期4-7,共4页
Contemporary Medicine
关键词
阿加曲班
丁苯酞
急性脑梗死
神经功能
认知功能
生命质量
Argatroban
Butyphthalide
Acute cerebral infarction
Neural function
Cognitive function
Quality of life
