摘要
重症肌无力(MG)是一种累及神经-肌肉接头突触后膜递质传递障碍的自身免疫性疾病,其并不影响女性生育能力,故妊娠合并MG并不罕见。妊娠合并MG患者的治疗方案需根据肌无力严重程度、相关治疗方式的疗效及其对妊娠可能产生的不良影响等因素进行个体化选择。孕期应特别注意避免药物和其他可能导致病情恶化的因素(如尿路感染),母亲为MG的新生儿可能出现新生儿暂时性MG(TNMG),需严密观察病情,尤其需注意呼吸状态及延髓肌群有无受影响。妊娠合并MG及其新生儿治疗成功的关键在于产科、神经科、麻醉科及新生儿科医生的多学科共同管理,对改善孕妇及新生儿预后至关重要。
Myasthenia gravis(MG)is an autoimmune disease that affects neuro-muscular junction neurotransmitter transmission disorders in postsynaptic membranes,it does not affect female fertility,so pregnancy with MG is not uncommon.The treatment of MG during pregnancy needs to be individualized depending on the severity of MG,as well as the efficacy of various treatment modalities and their possible harmful effects on pregnancy.Besides,special attention should be taken to avoid medications and other factors(such as urinary tract infections),which may make the condition worse.Transient neonatal MG(TNMG)may occur in newborns whose mothers are MG,and the condition should be closely observed,especially the respiratory status and whether the bulbar muscles are affected.The key to successful treatment of pregnancy with MG and its neonates lies in the multidisciplinary management of obstetrics,neurology,anesthesiology and neonatology,which is very important to improve the prognosis of pregnant women and newborns.
作者
苏娜
宋阳
SU Na;SONG Yang(Department of Pediatrics,Qilu Hospital of Shandong University,Qingdao,Shandong,266000,China)
出处
《当代医学》
2022年第26期190-194,共5页
Contemporary Medicine
关键词
重症肌无力
妊娠
新生儿
治疗
Myasthenia gravis
Pregnancy
Neonatal
Treatment
作者简介
通信作者:宋阳,E-mail:342349845@qq.com。
