摘要
目的分析血清肌钙蛋白I(cTnI)、肌酸激酶同工酶(CKMB)、肌红蛋白(Myo)、尿酸(UA)、脑钠肽(BNP)水平变化与老年慢性心力衰竭(CHF)患者心功能分级的关系及临床意义。方法选取2019年1月至2022年4月河南大学淮河医院收治的103例老年CHF患者作为心力衰竭组,根据老年CHF患者心功能分级将其分为Ⅱ级组(n=28)、Ⅲ级组(n=44)和Ⅳ级组(n=31),选取同期在本院接受体检的100名健康体检者作为健康对照组,比较两组及不同心功能分级老年CHF患者血清c TnI、CKMB、Myo、UA、BNP水平及健康对照组、不同心功能分级老年CHF患者平均室壁应力(MWS)、左心室质量指数(LVMI)、左心室射血分数(LVEF),采用Pearson相关分析血清因子与老年CHF患者血清因子与心功能分级和心功能指标的相关性。结果心力衰竭组血清cTnI、CKMB、Myo、UA、BNP水平高于健康对照组,差异有统计学意义(P<0.05)。不同心功能分级老年CHF患者血清cTnI、CKMB、Myo、UA、BNP水平呈升高趋势,组间比较差异具有统计学意义(P<0.05)。健康对照组及不同心功能分级老年CHF患者MWS、LVMI呈升高趋势,LVEF呈降低趋势,组间比较差异具有统计学意义(P<0.05)。Pearson相关分析结果显示,老年CHF患者血清cTnI、CKMB、Myo、UA、BNP水平与心功能分级及MWS、LVMI呈显著正相关关系(P<0.05),与LVEF呈显著负相关关系(P<0.05)。结论老年CHF患者血清cTnI、CKMB、Myo、UA、BNP水平升高,其与患者心功能分级及MWS、LVMI呈显著正相关关系,与LVEF呈显著负相关关系,血清cTnI、CKMB、Myo、UA、BNP水平有助于老年CHF的早期诊断及临床治疗方案的制定与选择。
Objective To analyze the relationship between serum troponin I(cTnI),creatine ki⁃nase isoenzyme(CKMB),myoglobin(Myo),uric acid(UA),brain natriuretic peptide(BNP)levels and car⁃diac function grade in elderly patients with chronic heart failure(CHF)and its clinical significance.Methods A total of 103 elderly CHF patients admitted to Huaihe Hospital of Henan University from January 2019 to April 2022 were selected as the heart failure group.According to the cardiac function classification of elderly CHF pa⁃tients,they were divided into the GradeⅡgroup(n=28),the GradeⅢgroup(n=44)and the GradeⅣgroup(n=31).100 healthy subjects who received physical examination in our hospital during the same period were se⁃lected as the healthy control group.The serum levels of cTnI,CKMB,Myo,UA and BNP in the two groups and in the elderly CHF patients with different cardiac function grades were compared with the healthy control group and the mean ventricular wall stress(MWS),left ventricular mass index(LVMI)and left ventricular ejection fraction(LVEF)in the elderly CHF patients with different cardiac function grades.Pearson correlation was used to analyze the correlation between serum factors and serum factors of elderly CHF patients with cardi⁃ac function grades and cardiac function indexes.Results The serum levels of cTnI,CKMB,Myo,UA and BNP in the heart failure group were higher than those in the healthy control group,and the difference was statistically significant(P<0.05).Serum cTnI,CKMB,Myo,UA,and BNP levels in elderly CHF patients with different cardiac function grades tended to increase,and the differences between groups were statistically significant(P<0.05).In the healthy control group and elderly CHF patients with different cardiac function grades,MWS and LVMI showed an increasing trend,and LVEF showed a decreasing trend,and the difference between the groups was statistically significant(P<0.05).Pearson correlation analysis showed that serum levels of cT⁃nI,CKMB,Myo,UA and BNP were significantly positively correlated with cardiac function grade,MWS and LVMI in elderly patients with CHF(P<0.05),and there was a significant negative correlation with LVEF(P<0.05).Conclusion Serum levels of cTnI,CKMB,Myo,UA and BNP in elderly CHF patients were in⁃creased,which were significantly positively correlated with cardiac function grade,MWS and LVMI,and nega⁃tively correlated with LVEF.Therefore,the levels of serum cTnI,CKMB,Myo,UA and BNP are helpful for the early diagnosis of CHF in the aged and the formulation and selection of clinical treatment plans.
作者
徐慧敏
李丹丹
刘玉茹
李彦明
XU Huimin;LI Dandan;LIU Yuru;LI Yanming(Department of Geriatric Medicine,Huaihe Hospital,Henan University,Kaifeng,Henan,China,450001;Department of Endocrinology,Huaihe Hospital,Henan University,Kaifeng,Henan,China,450001;Department of Cardiovascular Medicine,Huaihe Hospital,Henan University,Kaifeng,Henan,China,450001)
出处
《分子诊断与治疗杂志》
2023年第6期1042-1046,共5页
Journal of Molecular Diagnostics and Therapy
基金
河南省科技攻关项目(212102310789)。
作者简介
通信作者:徐慧敏,E⁃mail:xuhuimin2004@163.com。
