摘要
Background:Numerous studies have consistently demonstrated that high body mass index(BMI)is related to elevated serum alanine aminotransferase(ALT)among adults,but little is known about the association regarding adolescents,especially in China.In this study,we aimed to investigate the association between BMI and ALT activity among Chinese adolescents.Methods:A school-based cross-sectional study was performed among nine high schools in Shenzhen,China between February 2017 and June 2018.A generalized linear-regression model adjusting for age and gender was conducted,and bivariate correlation analysis between ALT and BMI was also performed.Results:A total of 7,271 adolescents aged from 9 years to 17 years were enrolled.Height,weight,BMI,and ALT were higher among boys than among girls(all P<0.001).The mean(standard deviation)of serum ALT levels was 14.26(14.77)U/L.In the entire BMI range,the BMIALT correlation was stronger for boys(Spearman’s r=0.396,P<0.001)and adolescents of 14 years17 years(r=0.356,P<0.001)than for girls(r=0.203,P<0.001)and adolescents of 9 years13 years(r=0.221,P<0.001),respectively.Serum ALT increased rapidly and followed a linear pattern from the point of BMI20.5 kg/m^(2),and each increase of 1 kg/m^(2)in BMI range above 20.5 kg/m^(2)was averagely correlated with an increase of 2.71 U/L in ALT levels(P<0.001).Conclusions:We found a significant BMIALT relationship.BMI at 20.5 kg/m^(2)may be a cut-off for evaluating serum ALT.BMIs27.1 kg/m^(2)for boys and24.9 kg/m^(2)for girls were linked to an elevated ALT activity for Shenzhen adolescents.
背景:许多研究一致认为,体质指数(BMI)较高的成年人丙氨酸氨基转移酶(ALT)水平相对较高,但在青少年人群中是否也存在此种相关性尚不明了,尤其是在中国青少年中。本研究旨在调查中国青少年中BMI与ALT的相关性。方法:2017年2月至2018年6月间,在深圳9所中学进行本项横断面研究。采用年龄和性别调整的广义线性回归模型及二元相关分析来明确BMI与ALT的相关性。结果:7271名9-17岁的青少年纳入研究。男生身高、体重、BMI和ALT均高于女生(均P<0.001)。血清ALT平均为14.16614.77 U/L。男生中BMI与ALT的相关性强于女生(r=0.396,P<0.001 vs r=0.203,P<0.001);14-17岁青少年中BMI与ALT的相关性强于9-13岁青少年(r=0.356,P<0.001 vs r=0.221,P<0.001)。当BMI≥20.5 kg/m^(2),血清ALT水平随BMI的增加显著升高,呈线性关系;BMI每增加1 kg/m^(2),ALT平均升高2.71 U/L(P<0.001)。结论:本研究发现BMI与ALT显著相关。20.5 kg/m^(2)或可作为BMI评估血清ALT的关键阈值。对于深圳青少年,可以将男生BMI≥27.1 kg/m^(2)和女生BMI≥24.9 kg/m^(2)作为筛查ALT升高的高危人群。
基金
supported by the Baoan District Medical and Health Basic Research Project[grant number:2018JD088].
作者简介
Corresponding author:Hua Zhou.Baoan Central Hospital of Shenzhen,the Fifth Affiliated Hospital of Shenzhen University,Shenzhen,Guangdong,P.R.China.Tel:+86-755-27956977,Fax:+86-755-27956977,Email:hua.zhou@email.szu.edu.cn。
