摘要
目的对巴斯德菌骨髓炎的临床特点进行分析,为该疾病的诊治提供参考。方法检索国内外巴斯德菌属引起骨髓炎的案例报道,提取文献中的病例资料如性别、年龄、既往史、动物接触史、合并感染、标本来源、感染途径、抗生素治疗方案与转归等进行分析,总结其临床特点并提出治疗建议。结果共22例患者纳入分析,均为国外文献报道,男性13例,女性9例,年龄以41-65岁居多(9例,40.9%)。13例有猫狗直接接触史,组织标本留取最多(13例,59.1%);多杀巴斯德菌是分离率最高的菌种(17例,77.3%);累及四肢骨最常见(12例,54.5%);通过细菌直接接种和邻近部位感染是巴斯德菌骨髓炎最常见的感染途径;目标治疗方案中青霉素类使用最多,其次为头孢类和喹诺酮类药物,疗程4周到6个月不等。17例患者好转,4例患者转归未提及,1例患者死亡。结论对于有猫狗等动物抓咬史的骨髓炎患者,要注意巴斯德菌感染可能。抗生素治疗方案可选择青霉素类、头孢类、氟喹诺酮类等,巴斯德菌骨髓炎预后一般较好。
Objective To analyze the clinical characteristics of Pasteur osteomyelitis and to provide reference for the diagnosis and treatment of the disease.Methods By searching domestic and foreign literature about Pasteur bacterial osteomyelitis cases,gender,age,past medical history and animal contact,merge infection,specimen source,infection,antibiotic treatment,and outcome were analyzed,and summarize the clinical characteristics and treatment recommendations.Results A total of 22 patients were included in the analysis,including 13 males and 9 females.All patients were reported in foreign literature.Most of the patients were 41-65 years old(9 cases,40.9%).13 patients had a history of direct contact with dogs and cats.Tissue samples were collected most(13 cases,59.1%).Pasteurella multocide was the most isolated strain(17 cases,77.3%).The involvement of limb bones was the most common(12 cases,54.5%);Direct inoculation and adjacent site infection are the most common routes of Pasteur osteomyelitis.In the target treatment regimen,penicillin was used most,followed by cephalosporins and quinolones.The course of treatment ranged from 4 weeks to 6 months.One patient died,the outcome of 4 patients was not mentioned,and the rest improved.Conclusion We should pay attention to the possibility of pasteuria infection in osteomyelitis patients with a history of scratches and bites from cats and dogs.Penicillin,cephalosporins,and fluoroquinolones can be selected as antibiotic treatment,pasteur osteomyelitis generally has a good prognosis.
作者
梁瑶
李吉博
蓝健
LIANG Yao;LI Ji-bo;LAN Jian(Department of Pharmacy,University of Chinese Academy of Sciences Shenzhen Hospital,Shenzhen 518106,Guangdong Province,China;Department of Intensive Care Unit,University of Chinese Academy of Sciences Shenzhen Hospital,Shenzhen 518106,Guangdong Province,China)
出处
《罕少疾病杂志》
2023年第6期65-67,共3页
Journal of Rare and Uncommon Diseases
关键词
巴斯德菌属
骨髓炎
文献分析
Pasteurella
Osteomyelitis
Literature Review
作者简介
第一作者:梁瑶,女,主管药师,主要研究方向:临床药学。E-mail:547334393@qq.com;通讯作者:蓝健,男,主治医师,主要研究方向:重症医学。E-mail:2470672506@qq.com。
