摘要
缺血性脑卒中的发生率和致死率多在清晨达到高峰,这种变化提示昼夜节律紊乱与急性缺血性脑卒中密切相关。虽然有研究认为,清晨血压升高(所谓的晨峰)、血小板聚集增加以及内皮功能的钝化与清晨缺血性脑卒中的发生相关,但其分子机制在很大程度上是未知的。近期研究发现,去乙酰酶沉默信息调节因子1(SIRT1)参与生物钟基因转录的调控过程。并且,SIRT1通过去乙酰化作用来抑制氧化应激、炎性反应、自噬及细胞凋亡等,在缺血性脑卒中的发生发展及治疗中发挥重要作用。因此,探讨昼夜节律和SIRT1之间的复杂关联以及他们在调节缺血性脑卒中神经保护中的相互作用非常必要。控制和定时管理SIRT1及生物钟蛋白或可成为缺血性脑卒中防治的新靶点。
The incidence and the mortality of ischemic stroke mostly peak in the early morning. This phenomenon suggests that circadian rhythm disorder is closely related to acute ischemic stroke. Although some studies believe that the rise of blood pressure (the so-called morning peak), the increase of platelet aggregation, and the passivation of endothelial function are related to the occurrence of early morning ischemic stroke, its molecular mechanism is largely unknown. Recent studies have found that deacetylase silent information regulator 1 (SIRT1) is involved in regulating clock gene transcription. Moreover, SIRT1 plays an important role in the occurrence, development and treatment of ischemic stroke by deacetylation to inhibit oxidative stress, inflammatory response, autophagy, and apoptosis. Therefore, it is necessary to explore the complex association between circadian rhythm and SIRT1 and their interaction in regulating neuroprotection against ischemic stroke.
作者
史静
郝晨曦
何苗
李伟荣
Shi Jing;Hao Chenxi;He Miao;Li Weirong(Department of Neurology,Ninth Clinical Medical College(Affiliated Taiyuan Central Hospital),Shanxi Medical University,Taiyuan 030009,China)
出处
《中华脑血管病杂志（电子版）》
2023年第2期154-158,共5页
Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
基金
山西省医学重点科研项目(2021XM14)。
关键词
昼夜节律
生物钟蛋白
沉默信息调节因子1
缺血性脑卒中
Circadian rhythm
Biological clock protein
Silent information regulator 1
Ischemic stroke
作者简介
通信作者:李伟荣,Email:weironglee@163.com。
