摘要
孤独症谱系障碍(autism spectrum disorder,ASD)是一种发病于儿童早期影响正常大脑发育的神经系统疾病。ASD发病率呈递增趋势,且目前尚无特效的治疗方法。ASD患者多存在胃肠道症状和肠道菌群失衡,且ASD患者的症状与肠道菌群结构密切相关,通过肠道菌群移植可明显改善ASD的症状。本文通过总结近年来关于肠道微生物群和ASD相关性的研究结果,并提出潜在的治疗干预措施,以恢复肠道微生物组的健康平衡,从而为更好地改善ASD的相关症状提供新思路。
Autism spectrum disorder(ASD)is a neurological disease that occurs in early childhood and affects normal brain development.The incidence of ASD is increasing,and there is no specific treatment.ASD patients mostly have gastrointestinal symptoms and intestinal flora imbalance,and the symptoms of ASD patients are closely related to the structure of intestinal flora,and the symptoms of ASD patients can be significantly improved by fecal microbiota transplantation.In this paper,we summarize the results of recent studies on the association between intestinal microbiome and ASD,and propose potential therapeutic interventions to restore the healthy balance of intestinal microbiome,so as to provide new ideas for improving the symptoms related to ASD.
作者
凌俊
陆明旭
LING Jun;LU Mingxu(Jiangbin Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China;不详)
出处
《中国医学创新》
CAS
2023年第14期169-174,共6页
Medical Innovation of China
基金
广西卫健委自筹经费科研课题(Z20211617)。
关键词
孤独症谱系障碍
肠道菌群
肠道菌群移植
Autism spectrum disorder
Intestinal flora
Fecal microbiota transplantation
作者简介
通信作者:陆明旭。
