摘要
目的 分析不同剂量瑞马唑仑在老年全麻手术患者中的应用效果。方法 选取2021年1月至9月我院60例老年全麻手术患者为研究对象,随机将其分为低剂量组(20例,给予0.2 mg/kg瑞马唑仑进行全麻诱导)、中剂量组(20例,给予0.3 mg/kg瑞马唑仑进行全麻诱导)、高剂量组(20例,给予0.4 mg/kg瑞马唑仑进行全麻诱导)。比较三组的麻醉效果。结果 脑电双频指数(BIS)≤60时(T_(1))、气管插管后5 min(T_(2))时,低剂量组的呼吸频率(RR)、平均动脉压(MAP)、呼气末二氧化碳(ETCO_(2))、脉搏血氧饱和度(SPO_(2))、中心静脉压(CVP)高于中剂量组、高剂量组,且中剂量组高于高剂量组(P<0.05)。低剂量组的BIS≤60耗时长于中剂量组、高剂量组,且中剂量组长于高剂量组(P<0.05);低剂量组补救措施采取率高于中剂量组、高剂量组(P<0.05);高剂量组麻醉苏醒期心动过缓、低氧血症发生率高于低剂量组、中剂量组(P<0.05)。低剂量组苏醒时BIS高于中剂量组、高剂量组,且中剂量组高于高剂量组(P<0.05);低剂量组麻醉苏醒室停留时间短于中剂量组、高剂量组,且中剂量组短于高剂量组(P<0.05)。术后5 min,中剂量组的去甲肾上腺素(NE)、皮质醇(Cor)、前列腺素E_(2)(PGE_(2))水平低于低剂量组、高剂量组,超氧化物歧化酶(SOD)水平高于低剂量组、高剂量组(P<0.05)。结论 中剂量瑞马唑仑用于老年全麻手术患者中,具有更高的安全性和有效性。
Objective To analyze the application effect of different doses of remimazolam in elderly patients undergoing general anesthesia surgery.Methods Sixty elderly patients undergoing general anesthesia surgery in our hospital from January to September 2021 were selected as the study subjects.The patients were randomly divided into low dose group(20 cases,receiving 0.2 mg/kg of remimazolam for general anesthesia induction),middle dose group(20 cases,receiving 0.3 mg/kg of remimazolam for general anesthesia induction)and high dose group(20 cases,receiving 0.4 mg/kg of remimazolam for general anesthesia induction).The anesthesia effects of the three groups were compared.Results When bispectral index(BIS)≤60(T_(1))and 5 min after tracheal intubation(T_(2)),the respiratory rate(RR),mean arterial pressure(MAP),end-tidal carbon dioxide(ETCO_(2)),pulse oxygen saturation(SPO_(2))and central venous pressure(CVP)in the low dose group were higher than those in the middle dose group and the high dose group,and those in the middle dose group were higher than the high dose group(P<0.05).The time of BIS≤60 in the low dose group was longer than that in the middle dose group and the high dose group,and that in the middle dose group was longer than the high dose group(P<0.05);the sampling rate of remedial measures in the low dose group was higher than that in the middle dose group and the high dose group(P<0.05);the incidences of bradycardia and hypoxemia in anaesthesia awakening period of the high dose group were higher than those of the low dose group and the middle dose group(P<0.05).The BIS during awakening in the low dose group was higher than that in the middle dose group and the high dose group,and that in the middle dose group was higher than the high dose group(P<0.05);the residence time of anesthesia recovery room in the low dose group was shorter than that in the middle dose group and the high dose group,and that in the middle dose group was shorter than the high dose group(P<0.05).At 5 min after operation,the levels of norepinephrine(NE),cortisol(Cor)and prostaglandin E_(2)(PGE_(2))in the middle dose group were lower than those in the low dose group and the high dose group,and the level of superoxide dismutase(SOD)was higher than that in the low dose group and the high dose group(P<0.05).Conclusion Middle dose remimazolam has higher safety and efficacy in elderly patients undergoing general anesthesia surgery.
作者
罗喜娜
LUO Xina(Anesthesiology Department,Puning People's Hospital,Puning 515300,China)
出处
《临床医学研究与实践》
2023年第17期69-72,共4页
Clinical Research and Practice
关键词
老年患者
全麻手术
瑞马唑仑
elderly patient
general anesthesia surgery
remimazolam
作者简介
罗喜娜(1990-),女,主治医师,学士。研究方向:手术麻醉。
