摘要
外泌体(exosomes,又称外切体)是细胞间通讯的重要媒介,目前已有研究表明,外泌体参与并影响抑郁症的发生、发展等过程。本文回顾外泌体在抑郁症发病机制、诊断、疗效评估及治疗等领域的研究进展,发现外泌体可通过调控神经炎症与神经发生等机制影响抑郁症状,并且外泌体自身及其所携带的miRNA、蛋白质等生物活性物质可作为抑郁症诊断、疗效评估及治疗的重要靶标。
Exosomes are important vectors of cellular communication.exosomes have been reported to be involved in and influence the occurrence,development,and other processes of depression.In this paper,we reviewed the research progress of exosomes in the pathogenesis,diagnosis,treatment and efficacy evaluation of depression.We found that exosomes can affect depressive symptoms by regulating neuroinflammation and neurogenesis.In addition,exosomes themselves and the bioactive substances carried by them,such as miRNA and proteins,can be used as important targets for the diagnosis,treatment and efficacy evaluation of depression.
作者
荣婧彤
孙思琦
刘忠纯
RONG Jingtong;SUN Siqi;LIU Zhongchun(Department of Psychiatry,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2023年第4期247-250,共4页
Chinese Journal of Nervous and Mental Diseases
基金
国家自然科学基金(编号:U21A20364)
国家重点研发计划(编号:2018YFC1314600)。
关键词
抑郁症
外泌体
神经炎症
神经发生
MIRNA
诊断
治疗
Major depressive disorder
Exosomes
Neuroinflammation
Neurogenesis miRNA
Diagnosis
Therapeutics
作者简介
通信作者:刘忠纯,E-mail:zcliu6@whu.edu.cn。
