摘要
目的分析雄激素受体(AR)在雌激素受体(ER)阳性与阴性乳腺癌患者中的表达及其临床意义。方法回顾性分析120例乳腺癌患者的病历资料,按ER的阴性、阳性的不同将其分为两组。其中75例ER阳性患者纳入观察组,45例ER阴性患者纳入对照组,统计对比AR在ER阳性、ER阴性患者中的表达差异;并分析AR表达与ER阳性、ER阴性患者的临床病理特征的关系;另分析AR表达与乳腺癌患者预后的关系。结果观察组AR阳性表达率[85.33%(64/75)]高于对照组[66.67%(30/45)],差异有统计学意义(P<0.05);在观察组中,AR表达与肿瘤组织学分级有关(P<0.05);在对照组中,AR表达与肿瘤组织学分级、神经侵犯、脉管侵犯、淋巴结转移、临床分期有关(P<0.05);观察组AR阳性表达患者的生存率[90.63%(58/64)]高于AR阴性表达患者[54.55%(6/11)],而对照组AR阳性表达患者的生存率[40.00%(12/30)]低于AR阴性表达者[73.33%(11/15)],差异有统计学意义(P<0.05)。结论AR阳性率在ER阳性与阴性乳腺癌患者间存在显著差异,且与患者临床病理特征的关系亦存在明显不同,与ER阴性的AR阳性表达乳腺癌患者相比,ER阳性表达的AR阳性表达患者具有更优良的预后。
Objective To analyze the expression of androgen receptor(AR)in estrogen receptor(ER)positive and negative breast cancer patients and its clinical significance.Methods 120 cases of breast cancer were retrospectively analyzed and divided into 2 groups according to the difference between ER negative and ER positive.Among them,75 ER positive patients were included in the observation group,and 45 ER negative patients were included in the control group.The expression differences of AR in ER positive and ER negative patients were statistically compared;And analyze the relationship between AR expression and the clinical pathological characteristics of ER positive and ER negative patients;In addition,the relationship between AR expression and prognosis of breast cancer patients was analyzed.Results The positive expression rate of AR in the observation group was[85.33%(64/75)],which was higher than that in the control group[66.67%(30/45)],with a statistically significant difference(P<0.05);In the observation group,AR expression was associated with tumor histological grading(P<0.05);In the control group,AR expression was associated with tumor histological grading,neural invasion,vascular invasion,lymph node metastasis,and clinical staging(P<0.05);The survival rate of AR positive expression patients in the observation group was[90.63%(58/64)]higher than that of AR negative expression patients in[54.55%(6/11)],while the survival rate of AR positive expression patients in the control group was[40.00%(12/30)]lower than that of AR negative expression patients in[73.33%(11/15)],with a statistically significant difference(P<0.05).Conclusion AR positive rate is significantly different between ER positive and ER negative breast cancer patients,and the relationship between AR positive rate and clinicopathological characteristics is also significantly different.Compared with ER negative AR positive breast cancer patients,ER positive AR positive patients have a better prognosis.
作者
陶豫洁
张琳
陈东辉
TAO Yujie;ZHANG Lin;CHEN Donghui(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471003)
出处
《实用癌症杂志》
2023年第6期879-881,887,共4页
The Practical Journal of Cancer
关键词
乳腺癌
雌激素受体
雄激素受体
预后
淋巴结转移
Breast cancer
Estrogen receptor
Androgen receptor
Prognosis
Lymph node metastasis
