摘要
目的探讨注意缺陷多动障碍(ADHD)患儿与正常儿童听觉失匹配负波(MMN)波幅及潜伏期的差异,研究MMN潜伏期及波幅用于评估ADHD患儿与正常儿童听觉感知注意能力的意义。方法于2022年12月1日,通过检索PubMed、Embase、Cochrane Library、中国知网(CNKI)、万方、维普数据库,系统收集关于ADHD患儿MMN的文献,并提取MMN波幅和潜伏期的数据。采用纽卡斯尔-渥太华文献质量评价量表(NOS)对纳入的文献进行质量评价。采用Stata 20.0进行Meta分析。结果最终纳入9篇文献,包括170名ADHD患儿和159名对照组,其中不同位点的MMN波幅相关数据共18组,不同位点的MMN潜伏期相关数据共10组。Meta分析结果显示,与对照组相比,ADHD组MMN波幅更低,差异无统计学意义(WMD=-0.334,95%CI:-1.426~0.758,P=0.549),ADHD组MMN潜伏期更长,差异有统计学意义(WMD=14.768,95%CI:4.660~24.876,P=0.004)。Bgger’s漏斗图提示不存在明显的发表偏倚。结论ADHD患儿MMN潜伏期较对照组长,提示ADHD患儿听觉感知注意能力可能降低。
Objective To explore the differences existing in the auditory mismatch negativity(MMN)amplitude and latency between children with attention deficit hyperactivity disorder(ADHD)and normal children,and to probe into the significance of MMN latency and amplitude for assessing the auditory perception and attention level in ADHD children and normal children.Methods On December 1,2022,a systematic search was performed in PubMed,Embase,Cochrane Library,China National knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service Platform and VIP databases to identify all well qualified literature focusing on MMN of ADHD children,then the valid data relevant to MMN amplitude and latency were extracted.The Newcastle-Ottawa Scale(NOS)was used to assess the quality of the included studies,and Stata 20.0 was employed for Metaanalysis.Results A total of 9 qualified studies comparing ADHD children(n=170)against healthy controls(n=159)were finally included.Among the included literature,there were 18 matched pairs of MMN amplitude data and 10 matched pairs of MMN latency data at different recording sites.Meta-analysis denoted that ADHD group resulted in potentials of slightly lower MMN amplitude(WMD=-0.334,95%CI:-1.426~0.758,P=0.549)and notably longer MMN latency(WMD=14.768,95%CI:4.660~24.876,P=0.004)compared to control group,and the Bgger's funnel plot did not reveal any publication bias.Conclusion Compared with healthy controls,ADHD children have longer MMN latency,suggesting that the auditory perception and attention level of ADHD children may be reduced.
作者
肖黎黎
刘春霞
杜雨欣
张弟文
王丽波
舒鑫
Xiao Lili;Liu Chunxia;Du Yuxin;Zhang Diwen;Wang Libo;Shu Xin(Sichuan Mental Health Center·The Third People's Hospital of Mianyang,Mianyang 621000,China)
出处
《四川精神卫生》
2023年第2期123-130,共8页
Sichuan Mental Health
基金
成都医学院四川应用心理学研究中心项目(项目名称:事件相关电位联合心理测验对注意缺陷多动障的评估,项目编号:CSXL-202A11)。
关键词
注意缺陷多动障碍
儿童
失匹配负波
META分析
Attention deficit hyperactivity disorder
Children
Mismatched negativity
Meta-analysis
作者简介
通信作者:张弟文,E-mail:24579736@qq.com。
