摘要
肠道菌群数量大、种类繁多,会对宿主产生各种各样的影响,包括营养代谢、免疫系统调节和抵御感染等,在维持肠道稳态平衡中起着重要作用。肠道上皮细胞是肠道防御系统的关键。肠道上皮是动物机体抵御微生物的第一道屏障,具有吸收和屏障功能,还是宿主与微生物群交流的主动传感器,而这样的功能是肠道菌群与肠上皮各类细胞间相互作用的结果。论文以肠道菌群与肠上皮细胞中的几类典型细胞之间的互作关系展开论述,旨在为如何通过各类细胞发挥的功能来协调肠道菌群的稳定,进而为预防或治疗某些由于肠道菌群失调而导致的疾病提供理论依据。
The large number and variety of intestinal flora have a variety of effects on the host,including nutrient metabolism,immune system regulation and resistance to infection,etc.,which play an important role in maintaining intestinal homeostasis.Intestinal epithelial cells are key to the intestinal defense system.The intestinal epithelium is the animal's first barrier against microorganisms.It has absorption and barrier functions,and is also an active sensor for host-microbiota dialogue,which is the result of interactions between intestinal flora and various types of intestinal epithelium cells.This article discussed the interaction between intestinal flora and several typical types of cells in intestinal epithelial cells,aiming to provide a theoretical basis for how to coordinate the stability of intestinal flora through the functions of each cell,and then provide a theoretical basis for the prevention or treatment of some diseases caused by intestinal dysbacteriosis.
作者
薛越
闫烁
姚文娜
赵宇龙
苏和
宋永利
李喜和
包花拉
包斯琴
XUE Yue;YAN Shuo;YAO Wen-na;ZHAO Yu-long;SU He;SONG Yong-li;LI Xi-he;BAO Hua-la;BAO Si-qin(Mongolian Plateau Animal Genetic Resources Research Center,College of Life Sciences,Inner Mongolia University,Hohhot 010070,China;Inner Mongolia Saikexing Institute of Livestock Breeding and Breeding Biotechnology,Hohhot 011517,China)
出处
《动物医学进展》
北大核心
2023年第5期86-91,共6页
Progress In Veterinary Medicine
基金
内蒙古科技厅重大专项(2021ZD0048):内蒙古自治区重大专项(2020ZD0007)
中央引导地方科技发展基金(2022ZY0135)。
关键词
肠道菌群
肠道上皮细胞
黏液
intestinal flora
intestinal epithelial cells
mucus
作者简介
薛越(1999-),女,内蒙古鄂尔多斯市人,硕士生,主要从事宿主-微生物间相互作用机制研究,同等贡献作者;闫烁(1994-),男,内蒙古呼和浩特市人,博士生,主要从事肠道微生物研究,同等贡献作者;通讯作者:包花拉;通讯作者:包斯琴。
