摘要
目的探讨血尿酸/高密度脂蛋白胆固醇比值(UHR)与新诊断T2DM患者IR的相关性,评估UHR预测IR的价值。方法选取2021年1月至2022年2月于徐州医科大学附属医院内分泌科治疗的新诊断T2DM患者304例(T2DM组),另选取同期体检健康者101名为正常对照(NC)组。比较两组一般资料及生化指标,计算甘油三酯葡萄糖乘积(TyG)指数、UHR及胰岛素抵抗指数(HOMA2-IR)。根据HOMA2-IR四分位数将T2DM组分为非IR亚组(N-IR,n=228)和IR亚组(IR,n=76),比较两亚组一般资料及生化指标。结果T2DM组HOMA2-IR、TyG指数、UHR高于NC组(P<0.05或P<0.01)。与N-IR亚组比较,IR亚组BMI、白细胞计数(WBC)、中性粒细胞计数(NE)、淋巴细胞计数(LY)、血尿酸(SUA)、FPG、TG、TyG指数、UHR升高(P<0.05或P<0.01),年龄、HDL-C降低(P<0.05或P<0.01)。Spearman相关分析显示,IR与BMI、WBC、NE、LY、FPG、TG、SUA、TyG指数、UHR呈正相关(P<0.05或P<0.01),与年龄、HDL-C呈负相关(P<0.01)。Logistic回归分析显示,BMI、TyG指数、UHR是新诊断T2DM患者IR的影响因素。受试者工作特征(ROC)曲线分析显示,BMI、TyG指数、UHR预测新诊断T2DM患者IR发生的ROC曲线下面积为0.781、0.700、0.749。结论UHR与新诊断T2DM患者IR相关,是IR发生的影响因素;UHR对新诊断T2DM患者IR风险有较好的预测价值。
Objective To investigate the relationship between serum uric acid/high density lipoprotein cholesterol ratio(UHR)and insulin resistance(IR)in patients with newly diagnosed type 2 diabetes mellitus(T2DM),and to assess its application in evaluating IR.MethodsA total of 304 patients with newly diagnosed T2DM(T2DM group)were selected in the Department of Endocrinology of the Affiliated Hospital of Xuzhou Medical University from January 2021 to February 2022.101 healthy individuals confirmed by physical examination during the same period were selected as the normal control(NC)group.The general clinical data and biochemical indexes were collected.The triglyceride-glucose index(TyG),UHR and homeostasis model assessment for insulin resistance(HOMA2-IR)were calculated.T2DM patients were further divided into non-IR subgroup(N-IR,n=228)and IR subgroup(IR,n=76)based on the quartile of HOMA2-IR.ResultsHOMA2-IR,TyG index and UHR were higher in T2DM group than in NC group(P<0.05 or P<0.01).Compared with N-IR subgroup,BMI,white blood cell count(WBC),neutrophil count(NE),lymphocyte count(LY),serum uric acid(SUA),FPG,TG,TyG index and UHR increased in IR subgroup(P<0.05 or P<0.01),while age and HDL-C levels decreased(P<0.05 or P<0.01).Spearman correlation analysis showed that IR was positively correlated with BMI,WBC,NE,LY,FPG,TG,SUA,TyG index and UHR(P<0.05 or P<0.01),while it was negatively correlated with age and HDL-C(P<0.01).Logistic regression analysis showed that BMI,TyG index and UHR were influencing factors for IR in patients with newly diagnosed T2DM.Receiver operating characteristic(ROC)analysis showed that the area under the curve for BMI,TyG index and UHR to predict the occurrence of IR in newly diagnosed T2DM patients was 0.781,0.700 and 0.749,respectively.ConclusionUHR is associated with IR in newly diagnosed T2DM patients and is an influence factor in the develop of IR;UHR has a good predictive value for the risk of IR in newly diagnosed T2DM patients.
作者
陈张哲
葛丹
凌宏威
魏晶
韩啸
CHEN Zhangzhe;GE Dan;LING Hongwei(The First Clinical Medical College of Xuzhou Medical University,Xuzhou 221004,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2023年第4期246-250,共5页
Chinese Journal of Diabetes
作者简介
通信作者:凌宏威,Email:ling_hongwei@126.com。
