摘要
key components of the ribosome and the most abundant RNA species,the rRNAs are modified during ribosome formation.N^(6)-methyladenosine(m^(6)A)is a conserved RNA modification occurring on different RNA species including rRNAs.Recently,it has been reported that ZCCHC4 and METTL5 are methyltransferases that mediate m^(6)A modification of human 28S and 18S rRNA,respectively.The newly discovered biological functions of the two methyltransferases include regulation of mRNA translation,cell proliferation,cell differentiation,stress response,and other biological processes.Both of them,especially METTL5,have been proved to be associated with a variety of diseases such as intellectual disability,cancer,congenital dysplasia and have potential clinical application as biomarkers and therapeutic targets.
基金
This work was supported by grants from the National Natural Science Foundation of China(No.81722014 and 81970913)
State Key Laboratory of Oral Disease,China(No.SKLOD202008)
West China Hospital of Stomatology(No.RD-03-202010).
作者简介
Corresponding author:Quan Yuan,State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,No.14,3rd Section,South Renmin Road,Chengdu,Sichuan 610041,China.E-mail address:yuanquan@scu.edu.cn。
