摘要
目的观察利拉鲁肽联合甘精胰岛素治疗新发超重2型糖尿病患者的疗效以及对胰岛功能的影响。方法选取2019年10月—2021年1月青铜峡市人民医院收治的50例新发超重2型糖尿病患者作为研究对象,随机分为对照组和观察组,各25例。对照组予以甘精胰岛素治疗,观察组予以利拉鲁肽联合甘精胰岛素治疗。对比两组患者治疗前后的临床指标。结果治疗后,观察组空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、体质指数(BMI)、腰围(WC)、三酰甘油(TG)、总胆固醇(TC)、空腹C肽水平(FCP)均优于对照组,差异有统计学意义(P<0.05)。结论利拉鲁肽联合甘精胰岛素治疗新发超重2型糖尿病可安全有效地控制血糖、血脂、体质量,改善胰岛素敏感性。
Objective To observe the efficacy of Liraglutide combined with insulin glargine in the treatment of newly overweight patients with type 2 diabetes mellitus and the effect on islet function.Methods 50 newly diagnosed overweight type 2 diabetes patients admitted to Qingtongxia People's Hospital from October 2019 to January 2021 were selected as research subjects and randomly divided into control group and observation group,with 25 patients in each group.The control group was treated with insulin glargine,and the observation group was treated with liraglutide combined with insulin glargine.Compare the clinical indicators of the two groups before and after treatment.Results After treatment,the observation group of fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c),constitution index(BMI),waist circumference(WC),triacylglycerol(TG),total cholesterol(TC),fasting C peptide level(FCP)were better than the control group,the difference was statistically significant(P<0.05).Conclusion Liraglutide combined with insulin glargine in the treatment of newly diagnosed overweight type 2 diabetes can effectively and safely control blood glucose,blood lipid,body weight and improve insulin sensitivity.
作者
叶小波
周源
YE Xiaobo;ZHOU Yuan(Department of Endocrinology,Qingtongxia People's Hospital,Qingtongxia,Ningxia Hui Autonomous Region,751600 China)
出处
《糖尿病新世界》
2023年第1期66-68,89,共4页
Diabetes New World Magazine
关键词
2型糖尿病
利拉鲁肽
甘精胰岛素
血糖
Type 2 diabetes mellitus
Liraglutide
Insulin glargine
Blood glucose
作者简介
叶小波(1978-),男,本科,副主任医师,研究方向为糖尿病。
