摘要
目的探讨采用低频振幅(ALFF)法分析伴消极完美主义首发抑郁症患者特征性脑功能改变及其与临床症状的相关性。方法纳入2020—2022年招募的44例首发抑郁症患者,其中男11例,女33例,年龄(24.64±5.31)岁,根据中文Frost多维度完美主义量表(CFMPS)中消极完美主义总分将患者分为抑郁伴消极完美主义(DANP)组24例和抑郁不伴消极完美主义(DWNP)组20例。分析比较两组ALFF值的差异,将差异有统计学意义的脑区提取ALFF值与CFMPS量表中消极完美主义总分、17项汉密尔顿抑郁量表(HAMD-17)总分进行Pearson相关性分析。结果与DWNP组相比,DANP组右侧额中回、右侧顶下缘角回、右侧脑岛、左侧颞下回、左侧颞中回ALFF值显著升高,左侧中央旁小叶、左侧额中回、左侧缘上回、左侧三角部额下回、左侧岛盖部额下回ALFF值显著降低。右侧额中回ALFF值与消极完美主义总分和HAMD-17总分呈负相关(r=-0.531,P=0.008;r=-0.477,P=0.018)。结论DANP患者较DWNP患者的脑功能存在异常,这些异常主要表现在与情绪、认知等有关的额叶、颞叶、顶叶,且右侧额中回代偿功能越强,消极完美主义及抑郁严重程度越弱。
Objective To investigate the differences in whole brain activity between patients with and without negative perfectionism first-episode depression using the amplitude of low-frequency fluctuations(ALFF)method and to investigate their associations with clinical symptoms.Methods Forty-four first-episode depression patients,including 11 males and 33 females,aged(24.64±5.31)years,were recruited during 2020 and 2022,and were included in this study.The patients were divided into the depression accompanied by negative perfectionism group(the DANP group,n=24)and the depression without negative perfectionism group(the DWNP group,n=20)according to the total scores of negative perfectionism on the Chinese Frost Multidimensional Perfectionism Scale(CFMPS).Independent sample t-test analysis was used to compare the differences in ALFF values between the two groups,and Pearson correlation analysis was performed between the extracted ALFF values of brain regions with statistically significant differences and the total scores of negative perfectionism on the CFMPS and the total scores of the 17-Item Hamilton Depression Scale(HAMD-17).Results Compared with the DWNP group,the DANP group had significantly higher ALFF values in the right middle frontal gyrus,right inferior parietal marginal angular gyrus,right insula,left inferior temporal gyrus and left middle temporal gyrus,and had significantly lower ALFF values in the left paracentral lobule,left middle frontal gyrus,left superior marginal gyrus,left triangular inferior frontal gyrus and left insular cap frontal gyrus.Correlation analysis showed that the right middle frontal gyrus ALFF value was negatively correlated with the total negative perfectionism score and negatively correlated with the total HAMD-17 score(r=-0.531,P=0.008;r=-0.477,P=0.018).Conclusion The DANP patients have abnormal brain functions compared with the DWNP patients,and these abnormalities are mainly in the frontal,temporal,and parietal lobes,which are related to emotion and cognition,and the stronger the compensatory function of the right middle frontal gyrus,the weaker the severity of the negative perfectionism and depression.
作者
范春华
周瀛
陈雁菁
刘萍
易思婕
李卫晖
刘军
FAN Chun-hua;ZHOU Ying;CHEN Yan-jing(Department of Radiology,the Second Xiangya Hospital of Central South University,Changsha 410011,China)
出处
《中国临床新医学》
2023年第4期311-316,共6页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
国家科技部科技创新2030-重大项目(编号:2021ZD0200700)
湖南省科技创新计划项目(编号:2021RC4016)
湖南创新型省份建设专项项目(编号:2020SK4001)。
关键词
抑郁症
完美主义
磁共振成像
低频振幅
Depression
Perfectionism
Magnetic resonance imaging
Amplitude of low-frequency fluctuations
作者简介
范春华,在读硕士研究生,研究方向:抑郁症的神经影像学研究。E-mail:1662023227@qq.com;通信作者:刘军,医学博士,主任医师,博士研究生导师,博士后合作导师。博士毕业于中南大学湘雅二医院精神医学科,现任中南大学湘雅二医院放射科主任、党支部书记。研究方向为多模态精神影像、人工智能。现为国家自然科学基金同行评议专家、国家放射影像专业医疗质量控制中心专家委员会委员、中国医师协会放射医师分会全国委员、中国神经影像及神经再生学组组长、中华放射学会神经放射专业委员会全国委员,为国家脑计划研究核心骨干成员。担任Meta-Radiology执行主编,Neural Regeneration Research编委,European Journal of Radiology、European Radiology、Frontiers in Oncology、《中华放射学杂志》、《磁共振成像》等审稿专家。近5年主持课题12项,其中包括国家联合基金重点支持项目1项,国家自然科学基金面上项目2项,湖南省重点研发计划项目2项,主编或参编专著7部,获得科研奖励5项。近5年,以第一及通信作者(含并列)发表论文92篇,其中SCI 80篇,在Lancet Digital Health、Radiology、Brain、Medical Image Analysis、Pattern Recognition、IEEE Transactions on Medical Imaging、American Journal of Roentgenology等顶刊发表SCI 33篇,IF≥10分论文14篇,IF≥5分论文35篇。获得科技部抗击新冠肺炎全国先进个人、湖南省科技创新领军人才、2019湖南省“225工程”医学学科带头人培养对象、人民名医(优秀风范奖)、中南大学“双带头人”教师党支部书记等多项荣誉称号。E-mail:junliu123@csu.edu.cn。
