摘要
环境内分泌干扰物分布广泛,严重威胁人体健康。过去几十年中,人类发现和合成了大量化合物,至今仍有许多化合物的生殖系统内分泌干扰效应不能明确。如何快速筛选识别环境内分泌干扰物并评估其生殖毒性,是需要重点关注的问题。本文对环境内分泌干扰物生殖毒性的筛选检测方法进行综述,总结其优势与局限性,为相关研究中方法选取提供参考。
Environmental endocrine disruptors(EEDs)are widely distributed in the environment and do great harm to the human body.In the past few decades,a large number of compounds have been discovered and synthesized,but the endocrine disrupting effects of many compounds on the reproductive system are still unclear.So,how to quickly screen and identify environmental endocrine disruptors and explore their reproductive toxicity need to be focused on.This article briefly reviews the screening and detection method for the reproductive toxicity of environmental endocrine disruptors,and summarizes their advantages and limitations,to provide reference for the selection of method in related research.Environmental endocrine disruptors(EEDs)are widely distributed and seriously threaten human health.In the past few decades,a large number of compounds have been discovered and synthesized,but the endocrine-disrupting effects of many compounds on the reproductive system are still unclear.How to quickly screen and identify EEDs and assess their reproductive toxicity is an issue that needs to be focused on.This article briefly reviews the detection methods of the reproductive toxicity of EEDs as well as their advantages and limitations,so as to provide a reference for the selection of methods in relevant research.
作者
秦鹏
陆姿蓉
王尚乾
QIN Peng;LU Zi-rong;WANG Shang-qian(The First Clinical Medical College,Nanjing Medical University,Nanjing 210029,Jiangsu,China;School of Pediatrics,Nanjing Medical University;Department of Urology The first Affiliated Hospital of Nanjing Medical University)
出处
《环境卫生学杂志》
2023年第4期294-301,共8页
JOURNAL OF ENVIRONMENTAL HYGIENE
基金
国家自然科学基金青年科学基金项目(81800587)
江苏省大学生创新创业计划(202210312073Y)。
关键词
环境内分泌干扰物
生殖毒性
检测方法
environmental endocrine disruptors
reproductive toxicity
detection method
作者简介
秦鹏,本科生,主要从事环境内分泌干扰物生殖毒理研究,Email:779114984@qq.com;通信作者:王尚乾,副主任医师,从事环境内分泌干扰物致雄性生殖系统发育障碍的毒理机制研究,Email:wsq5501@126.com。
