摘要
目的 观察生长抑素联合吲哚美辛对胆管癌患者内镜下逆行胰胆管造影术(ERCP)后并发症的预防效果。方法 选取2018年5月—2021年5月甘肃省第三人民医院收治的90例胆管癌患者作为研究对象,根据随机数字表分为常规组和研究组,每组45例。患者均接受ERCP治疗,其中常规组于术前采用生长抑素治疗,研究组在常规组基础上联合吲哚美辛栓治疗。比较2组患者术后胰腺炎、高淀粉酶血症发生率,术前及术后5、24 h血清淀粉酶(AMY)、脂肪酶(LPS)、天冬氨酸氨基转移酶(AST)水平及白细胞计数(WBC)。结果 2组患者术后高淀粉酶血症发生率比较差异无统计学意义(P>0.05);但研究组术后胰腺炎发生率低于常规组(P<0.05)。术后5、24 h, 2组血清AMY、LPS水平及WBC高于术前,但研究组血清AMY、LPS水平及WBC均低于常规组(P<0.05),但2组血清AST水平比较差异无统计学意义(P>0.05)。结论 生长抑素联合吲哚美辛在降低胆管癌患者ERCP后胰腺炎发生率上效果明显,可更有效地控制胰液水平,减轻炎性反应,且不会损伤肝功能。
Objective To study the prevention effect of somatostatin combined with indomethacin for complications after ERCP of cholangiocarcinoma patients.Methods In this study,90 cases of patients with cholangiocarcinoma treated in the Third People′s Hospital of Gansu Province from May 2018 to May 2021 were selected as the data subjects,and they were divided into the conventional group and the study group by random number table method,with 45 cases in each group.The conventional group was treated with somatostatin,and the study group was treated with somatostatin combined with indomethacin suppository.The incidence of postoperative pancreatitis,hyperamylasemia,serum levels of AMY,LPS,AST and WBC before operation and at 5,24 hours after operation were compared between the two groups.Results There was no statistical significance in the incidence of hyperamylasemia between the two groups(P>0.05).The incidence of postoperative pancreatitis in the study group was significantly lower than that in the conventional group(P<0.05).Serum levels of AMY,LPS and WBC at 5,24 hours after operation in the two groups were higher than those before operation,and the indexes of the study group were lower than those in the conventional group(P<0.05),and there was no significant difference of serum level of AST between the two groups(P>0.05).Conclusion Somatostatin combined with indomethacin can more effectively reduce incidence of pancreatitis after ERCP of cholangiocarcinoma patients,and can control pancreatic juice level,reduce inflammatory reaction,and will not damage liver function.
作者
乔建丽
刘瑞生
牟君
QIAO Jianli;LIU Ruisheng;MOU Jun(General Surgery,Third People′s Hospital of Gansu Province,Lanzhou 730000,China)
出处
《临床合理用药杂志》
2023年第9期19-22,共4页
Chinese Journal of Clinical Rational Drug Use
