摘要
质子放射治疗是现代癌症治疗的重要手段之一,由于其精确的靶区剂量递送和良好疗效而得到了广泛的关注.基于高功率激光器的激光质子加速技术有望通过小型化和低复杂度等优势为质子治疗提供具有竞争力的加速方案.同时,激光质子束还具有宽能谱、超高瞬态流强和超短脉冲等特点,为探究超高剂量率放疗导致的生物学效应及可能的优势提供了有利的研究条件.在过去的数年里,我们借助北京大学紧凑型激光等离子体加速器以及在建的北京激光加速创新中心实验平台,陆续开展了涵盖激光质子加速、束流传输控制、辐射生物学和免疫学等方面的理论与实验研究,以探讨激光质子放疗的可行性与优势.本文从这些方面对国内外前沿研究进行了总结,并着重探讨了剂量递送与生物学效应方面的研究进展和面临的问题,最后对激光质子放疗的未来发展前景进行了讨论和展望.
Proton radiotherapy is one of the most important modalities to treat cancers,which attracts a lot of attention for that it can precisely target the tumor with reduced side effects.However,due to the financial pressures of constructing and maintaining a proton radiotherapy center,nowadays this treatment method is not wildly available worldwide.In this context,the novel proton acceleration techniques based on high-power laser facilities are believed to become a competitive acceleration method,mainly for the advantages of compact size and low complexity.Meanwhile,the laser accelerated protons own some special features like broad energy spectrum,ultra-short pulse duration and ultra-high peak current,which would favor the research about radiobiological effects under ultra-high dose rate radiotherapy.As for laser-accelerator-based proton radiotherapy,the fundamental challenge nowadays lies on the proton energy that can be achieved(<100 MeV),which is not enough to completely meet the needs of human treatments,while we have seen the potential of the advanced target structure and cascaded acceleration to enhance the beam energy.Besides,quantities of in vitro and in vivo biological experiments have been carried out,benefiting from the adjunct development of beam transportation elements that are suitable for laser-accelerated protons,and biological phenomena that differ from the case of using conventional proton beams have been observed.Furthermore,compared with the standard dose rate radiotherapy,there are evidences showing the significant advantages of ultra-high dose rate radiotherapy in regulating immunity,which paves the way to a multidisciplinary field of radiobiology,immunology,and advanced acceleration technology,where there should be a place for laser accelerators.Additionally,the past two decades have witnessed the worldwide booming developments of petawatt class laser facilities,accompanied by the increasing peak power and declining cost per petawatt.This progress might promote the clinical use of laser accelerators in the future.In the past few years,we have carried out theoretical and experimental research concerned with laser proton acceleration,beam transportation,radiobiology and immunology based on the platforms of the Compact Laser Plasma Accelerator of Peking University and Beijing Laser Acceleration Innovation Center,in order to investigate the availability and probable advantages of tumor therapy by using laser-accelerated proton beams.In this review,the research status from these aspects at home and abroad is introduced,and the progress as well as problems is discussed especially in the dose delivery and biological effects.Finally,the future development of laser-accelerator-based proton therapy is discussed and prospected.
作者
吕建锋
罗筠彬
王超
马宇琦
赵兴益
吴笛
王科栋
赵家瑞
徐圣宣
耿易星
赵研英
朱昆
林晨
马文君
陈佳洱
颜学庆
杨根
Jianfeng Lü;Yunbin Luo;Chao Wang;Yuqi Ma;Xingyi Zhao;Di Wu;Kedong Wang;Jiarui Zhao;Shengxuan Xu;Yixing Geng;Yanying Zhao;Kun Zhu;Chen Lin;Wenjun Ma;Jiaer Chen;Xueqing Yan;Gen Yang(State Key Laboratory of Nuclear Physics and Technology,Peking University,Beijing 100871,China;Beijing Laser Acceleration Innovation Center,Beijing 101407,China;Institute of Guangdong Laser Plasma Advanced Technology,Guangzhou 510475,China;Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 352001,China;School of Public Health and Management,Wenzhou Medical University,Wenzhou 325035,China)
出处
《科学通报》
EI
CAS
CSCD
北大核心
2023年第9期1112-1124,共13页
Chinese Science Bulletin
基金
国家自然科学基金(11921006,11875079)
北京高等学校卓越青年科学家项目
国家重点研发计划(2019YFF01014400)
中国科学院高功率激光物理重点实验室开放基金(SGKF202104)资助。
关键词
激光加速器
质子放疗
剂量递送
生物学效应
laser accelerator
proton radiotherapy
dose delivery
biological effect
作者简介
联系人:颜学庆,E-mail:x.yan@pku.edu.cn;杨根,gen.yang@pku.edu.cn。
