摘要
目的:观察猪肺磷脂注射液与经鼻持续气道正压通气联合应用治疗新生儿呼吸窘迫综合征的临床效果。方法:选取2020年10月—2022年10月临沂市中心医院收治的新生儿呼吸窘迫综合征患儿76例,将患儿随机分为观察组和对照组每组各38例。对照组采用常规治疗和经鼻持续气道正压通气治疗,观察组则在对照组治疗的基础上加用猪肺磷脂注射液治疗。比较两组患儿的临床疗效、血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、经皮血氧饱和度(SpO_(2))]、正压通气时间、氧疗时间、住院时间。结果:治疗后,观察组总有效率(97.37%)高于对照组(84.21%),差异有统计学意义(P<0.05)。治疗后,差异有统计学意义(P<0.05),两组PaO_(2)、SpO_(2)均明显升高,PaCO_(2)明显降低。治疗后,观察组PaO_(2)、SpO_(2)水平高于对照组,PaCO_(2)水平低于对照组,差异有统计学意义(P<0.05)。观察组正压通气时间、氧疗时间及住院时间均短于对照组,差异有统计学意义(P<0.05)。结论:猪肺磷脂注射液与经鼻持续气道正压通气联合应用治疗新生儿呼吸窘迫综合征具有显著的临床效果,可有效改善患儿的血气指标,促进患儿康复,缩短治疗时间,值得临床应用。
Objective To observe the clinical efficacy of porcine pulmonary phospholipid injection combined with nasal continuous positive airway pressure in the treatment of neonatal respiratory distress syndrome(NRDS).Methods 76 children with NRDS admitted to Linyi Central Hospital from October 2020 to October 2022 were randomly divided into observation group and control group,with 38 cases in each group.The control group was treated with conventional therapy and nasal continuous positive airway pressure ventilation,while the observation group was treated with porcine pulmonary phospholipid injection on the basis of the treatment of the control group.The clinical efcacy,blood gas index(PaO_(2),PaCO_(2),SpO_(2)),positive pressure ventilation time,oxygen therapy time and hospitalization time were compared between the two groups.Results After treatment,the total effective rate of the observation group(97.37%)was higher than the control group(84.21%P<0.05).Compared with before treatment,PaO_(2)and SpO_(2)in the two groups were signifcantly increased,while PaCO_(2)was signifcantly decreased.After treatment,there were statistically differences in PaO_(2)and SpO_(2)of level in observation group were higher than those in control group,but,PaCO_(2)(P<0.05).The positive pressure ventilation time,oxygen therapy time and hospitalization time in the observation group were shorter than those in the control group(all P<0.05).Conclusion The treatment of neonatal respiratory distress syndrome with porcine pulmonary phospholipid injection combined with nasal continuous positive airway pressure has a good clinical effect,can effectively improve the blood gas index of children,promote the recovery of children,shorten the treatment time,and has a high clinical application value.
作者
熊纪昆
孙珍
XIONG Jikun;SUN ZHen(Neonatal Intensive Care Unit,Linyi Central Hospital,Linyi,Shandong 276400,China;Department of Gynecology,Linyi Central Hospital,Linyi,Shandong 276400,China)
出处
《医药前沿》
2023年第4期26-28,共3页
Journal of Frontiers of Medicine
关键词
猪肺磷脂注射液
经鼻持续气道正压通气
新生儿呼吸窘迫综合征
血气指标
Porcine pulmonary phospholipid injection
Nasal continuous positive airway pressure
Neonatal respiratory distress syndrome
Blood gas index
