摘要
老年痴呆是老年人致残致死主要疾病之一,主要有阿尔茨海默病(AD)和血管性痴呆(VD)2大疾病。结合前期对地黄饮子治疗老年痴呆疾病的实验研究基础,查阅近几年国内外文献,系统梳理地黄饮子对AD和VD病因病机,及地黄饮子对其作用机制和AD、VD与地黄饮子主治喑痱证的关系,阐释“AD、VD/喑痱证”具有协同性,在病/证结合上明确地黄饮子对老年痴呆疾病的作用机制,为今后地黄饮子防治老年痴呆的临床和实验研究提供参考。
Senile dementia which mainly include Alzheimer's disease(AD)and Vascular dementia(VD)is one of the main diseases causing disability and death in the elderly.Combined with previous experimental research of Dihuang Yinzi in the treatment of senile dementia,by reviewing literature at home and abroad in recent years,to systematically conclude etiology and pathogenesis and mechanism of action which Dihuang Yinzi treats AD and VD,as well as illustrate the relationship between AD and VD and Yinfei syndrome treated by Dihuang Yinzi,to explain the synergy of"AD,VD and Yinfei syndrome"and clarify the mechanism of action of Dihuang Yinzi on senile dementia in combination of disease and syndrome,thus providing reference for future clinical and experimental researches on prevention and treatment of senile dementia with Dihuang Yinzi.
作者
窦金金
罗泓楠
李红颖
张喜武
DOU Jinjin;LUO Hongnan;LI Hongying;ZHANG Xiwu(The First Afiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Experimental Training Center,Heilongjiang University of Chinese Medicine,Harbin 150040,China;The Second Hospital of Harbin,Harbin 150056,China)
出处
《现代中药研究与实践》
CAS
2023年第1期92-98,共7页
Research and Practice on Chinese Medicines
基金
国家自然科学基金面上项目(81873161)
黑龙江省自然科学基金项目(LH2019H102)
黑龙江省中医药管理局项目(ZHY18-065)
黑龙江省博士后科研启动基金(LBH-Q16215)。
关键词
地黄饮子
老年痴呆
阿尔茨海默病
血管性痴呆
研究进展
Dihuang Yinzi
senile dementia
Alzheimer's disease
Vascular dementia
research progress
作者简介
窦金金(1980-),女,博士,主任医师,研究方向:中西医结合防治心脑血管疾病。E-mail:doujinjin1980@126.com;通信作者:张喜武(1982-),男,博士,副研究员,研究方向:纳米靶向给药研究。E-mail:149772105@qq.com。
