摘要
骨质疏松症(OP)是一种全身性骨骼疾病,其特征是骨密度降低,骨微结构受损,可诱发脆性骨折。OP是一种多因素疾病,在绝经后妇女中更为常见,其较高的发病率和严重的并发症受到越来越多的关注。目前临床上抗骨质疏松的药物主要分为抑制骨吸收和促进骨形成两类,包括二磷酸盐、降钙素、雌激素等,但药物的不良反应及高昂经济成本在一定程度上限制其使用范围。近年来,肠道菌群对骨骼健康特别是对骨质疏松症的影响的研究逐渐深入,成为调节骨密度的潜在新靶点。益生菌属于肠道菌群,被定义为活的微生物,其在部分骨代谢疾病治疗中已初步展现了较好疗效,提示肠道菌群可作为骨质疏松防治的潜在靶点,且益生菌的应用可作为骨质疏松的新治疗方法。本文主要通过对益生菌与OP的相关研究进行综述,展示益生菌干预OP的最新研究进展,阐明益生菌通过肠道干预OP的相关作用机制,分析益生菌治疗OP的研究现状及前景。
Osteoporosis(OP)is a systemic bone disease characterized by decreased bone density and damage to bone microstructure,leading to brittle fractures.It is a multifactorial disease that is more common in postmenopausal women,and its high incidence and serious complications are receiving increasing attention.Currently,clinical anti-osteoporosis drugs are mainly divided into two categories:inhibiting bone resorption and promoting bone formation,including bisphosphonates,calcitonin and estrogen,etc.But the side effects and high economic cost of drugs limit the scope of their use to some extent.In recent years,the effect of intestinal flora on bone health,especially on osteoporosis,has become a potential new target for regulating bone density.Probiotics belong to intestinal flora and are defined as living microorganisms.They have initially shown good efficacy in the treatment of some bone metabolic diseases,suggesting that intestinal flora can be used as a potential target for the prevention and treatment of osteoporosis and the application of probiotics as a new therapeutic method for osteoporosis.This paper mainly reviews the relevant studies on probiotics and osteoporosis,shows the latest research progress of probiotics intervention in OP,clarifies the relevant action mechanism of probiotics intervention in OP through intestinal tract,and analyzes the research status and prospect of probiotics treatment in OP.
作者
高谱
殷浩
贺学军
Gao Pu;Yin Hao;He Xuejun(Department of Orthopaedics,Hunan Provincial People′s Hospital(the First Affiliated Hospital of Hunan Normal University),Changsha 410005,China)
出处
《中国医师杂志》
CAS
2023年第3期468-472,共5页
Journal of Chinese Physician
基金
湖南省自然科学基金科卫联合项目(2019JJ80010)。
关键词
骨质疏松
益生菌
肠道菌群
雌激素
Osteoporosis
Probiotics
Intestinal flora
Estrogen
作者简介
通信作者:贺学军,Email:1019065798@qq.com。
