摘要
目的分析柴芩攻毒方治疗湿热毒瘀型重症急性胰腺炎(SAP)的疗效。方法选取2018年1月—2021年1月于甘肃省庆阳市中医医院接受治疗的湿热毒瘀型SAP患者80例,依据随机数字表法分为基础治疗组(37例)和联合治疗组(43例),基础治疗组采用谷氨酰胺治疗,联合治疗组采用谷氨酰胺联合柴芩攻毒方治疗,观察并对比两组预后指标、D-二聚体(D-D)水平、改良CT严重指数(MCTSI)评分、Balthazar分级、免疫功能指标、肠黏膜功能指标、中医证候积分、急性生理和慢性健康状况(APACHEⅡ)评分及治疗效果。结果与基础治疗组相比,联合治疗组住院时间、肠功能恢复时间、全身炎症反应综合征持续时间均较短(P<0.01),转重症加强护理病房率、死亡率、D-二聚体水平、改良CT严重指数评分、Balthazar分级、CD4^(+)/CD8^(+)、肠黏膜功能指标、中医证候积分、APACHEⅡ评分均较低(P<0.01,P<0.05),CD3^(+)、CD4^(+)、CD8^(+)、治疗总有效率较高(P<0.01,P<0.05)。结论柴芩攻毒方联合谷氨酰胺在湿热毒瘀型SAP治疗中有助于改善患者临床指标,减轻机体炎症反应,增强免疫功能,保护胃肠黏膜屏障,值得临床推广。
Objective To analyze the therapeutic effect of Chaiqin Gongdu Formula on severe acute pancreatitis(SAP)with dampness–heat toxin and stasis.Methods Eighty SAP patients with dampness–heat toxin and stasis who were treated in Qingyang Hospital of Traditional Chinese Medicine,Gansu Province from January 2018 to January 2021 were selected,and divided into a basic treatment group(n=37)and a combined treatment group(n=43)by random number table method.The basic treatment group was given glutamine alone,while the combined treatment group was given glutamine and Chaiqin Gongdu Formula.The prognosis indexes,D-dimer(D-D)level,modified CT severity index(MCTSI)score,Balthazar score,immune function indexes,intestinal mucosal function indexes,traditional Chinese medicine(TCM)syndrome score,Acute Physiology and Chronic Health Evaluation(APACHEⅡ)score and treatment effect of the two groups were observed and compared.Results Compared with the basic treatment group,the combined treatment group had shortened hospitalization,recovery time of intestinal function,and systemic inflammatory response syndrome(SIRS)duration(P<0.01).The rate of transfer to intensive care unit(ICU),mortality,D-D level,MCTSI score,Balthazar score,CD4^(+)/CD8^(+),intestinal mucosal function indexes,TCM syndrome score,and APACHEⅡscore in the combined treatment group were lower(P<0.01,P<0.05),while CD3^(+),CD4^(+),CD8^(+)and total effective rate were higher(P<0.01,P<0.05)than the basic treatment group.Conclusion Chaiqin Gongdu Formula combined with glutamine helps improve the clinical indexes of patients,reduce inflammatory reaction of the body,enhance immune function,and protect gastrointestinal mucosal barrier in the treatment of SAP with dampness–heat toxin and stasis,which is worthy of clinical promotion.
作者
权刚
QUAN Gang(Intensive Care Unit,Qingyang Hospital of Traditional Chinese Medicine,Gansu Province,Qingyang 745000,China)
出处
《基层中医药》
2023年第1期69-75,共7页
Basic Traditional Chinese Medicine
关键词
柴芩攻毒方
谷氨酰胺
重症急性胰腺炎
Chaiqin Gongdu Formula
glutamine
severe acute pancreatitis
作者简介
通讯作者:权刚,E-mail:quangang168@163.com。
