摘要
肠道微生态与新生儿生长发育、神经系统发展及新生儿疾病关系是近年研究热点之一。肠道菌群可影响新生儿膳食成分代谢消化等重要生理过程。因出生后所处环境、喂养方式等与足月儿不同,低出生体重早产儿肠道菌群定植和演变过程与足月儿存在差异。稳定的肠道菌群及完整的肠黏膜屏障可限制肠道致病菌生长,肠道菌群失调与多种新生儿疾病相关。因此,本文总结了低出生体重早产儿肠道菌群特征、影响因素及远期关联、干预措施等方面的研究进展,以期为国内学者建立理论基础,提供治疗思路。
The relationship between intestinal microecology and neonatal growth and development, nervous system development and neonatal disease is one of the hot topics in recent years. The gut microbiota affects vital processes such as metabolism and digestion of dietary components. The colonization and evolution of intestinal flora of low birth weight preterm infants are different from those of full-term infants due to their different environment and feeding methods after birth. Stable gut microbiota and intact intestinal mucosal barrier can limit the growth of intestinal pathogens, and the imbalance of intestinal flora is associated with a variety of neonatal diseases. Therefore, this paper summarized the research progress in the characteristics, influencing factors, long-term association and intervention measures of intestinal flora of premature infants with low birth weight, in order to establish a theoretical basis for domestic scholars and provide treatment ideas.
作者
郭杉
刘瑞霞
阴赪宏
GUO Shan;LIU Ruixia;YIN Chenghong(Department of Central Laboratory,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China;Department of Central Laboratory,Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)
出处
《中国妇幼健康研究》
2023年第2期12-17,共6页
Chinese Journal of Woman and Child Health Research
基金
北京市自然科学基金(S160003)。
关键词
肠道菌群
肠道微生态
早产
低出生体重儿
gut microbiota
intestinal microecology
preterm
low birth weight infants
作者简介
郭杉(1994-),女,在读博士研究生,主要从事儿童肠道菌群发育研究;通讯作者:阴赪宏,医学博士、主任医师、教授、博士生导师,现任首都医科大学附属北京妇产医院党委副书记、院长。主要从事出生缺陷和大数据研究,作为课题负责人主持“十三五”国家重点研发计划,建立出生人口队列开展“重大出生缺陷风险研究”项目,已建成覆盖全国7大区、20个省市的前瞻性出生人口队列,构建35万余名孕妇孕早、中、晚期及产后42天的不良妊娠结局生殖健康数据库,以及200万份生物样本和互联全国统一管理的资源共享平台。主持国家科技支撑重点项目、国家自然科学基金等39项课题,在《The New England journal of medicine》《Human Reproduction Update》《Environment International》等杂志发表论文500篇,其中SCI收录期刊论文117篇,主编、副主编、副主译医学专著26部.
